このエントリーをはてなブックマークに追加
ID 13898
Eprint ID
13898
FullText URL
Title Alternative
Effect of chronic ethanol administration on mitochondrial membrane fluidity in rat liver and kidneys
Author
Jisho, Takayoshi
Abstract
The mitochondrial membrane fluidity in the rat liver and kidneys was measured by electron spin resonance spectrometry using spin labels 5- and 16-doxyl stearic acid (5-, 16-DS) after administration of an ethanol solution (7%) for 3 weeks. The order parameter, calculated from the 5-DS spectra, which is utilized for assessing the fluidity of the lipid bilayer near the surface of the membrane, increased significantly in the liver of the ethanol-administered group compared with the control group. No significant difference in the order parameter was observed in the kidney. On the other hand, in the motion parameter from the 16-DS spectra, which is utilized for the core of the lipid bilayer, no significant change was observed in either the liver or the kidneys. These findings indicated that the mitochondrial membrane fluidity decreased, by chronic ethanol administration, in the lipid bilayer near the surface in the rat liver, but no fluidity change was observed in the rat kidney.
Keywords
エタノール
膜流動性
ミトコンドリア膜
肝臓
腎臓
Note
原著
Published Date
1994-12
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1177
End Page
1181
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/11-12/106_11-12_1177/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma