start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=9 article-no= start-page=1415 end-page=1427 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fundamental and Clinical Studies on Medical Treatment of Moniliasis with Photosensitizing Dyes. Part. Ⅰ The relation between constitutional formulas of photosensitizing dyes and anticandida action and influences of photosensitizing dye NK 91 upon Candida albicans kn-title=感光色素によるモニリヤ症治療に関する基礎的並に臨床的研究 第1編 感光色素の構造式と抗Candida作用との関連性並に感光色素NK 91号のCandida albicansに及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author has investigated a specific fungiostatic action against Candida albicans Tanimoto by using 109 different species of photosensitizing dyes, classifing them into groups according to their constitutional formulas. Among so many species photosensitizing dye NK 91 which belongs to Styril type showed the strongest fungiostatic action and scareely decreased its effect by adding serum. The results obtained can be summarized as follows: 1) In respect of the types of dyes, Monomethin, Trimethin, Heptamethin, Cyanin and Styril types showed a strong fungiostatic action. 2) In respect of the radical nucleus (of dyes, Benzothiazol. Naphtothiazol and Chinorin nucleus showed a moderate fungiostatic action). 3) In respect of the alkyl radical, high alkyl did not always show the fungiostatic effect. 4) In regard to Halogen and acid radical, eight kinds of iodine radical, one kind of bromine radical, and three kinds of acid radical were efficacious. 5) NK 91 changed remarkably the shape of Candida albicans and moreover in the high concentration, perished utterly Candida albicans. 6) NK 91 inhibited the decline of pH of Sabouraud-glucose medium in which Candida albicans was inoculated. 7) The respiration of Candida albicans was inhibited and its oxygen consumption lowered by NK 91. en-copyright= kn-copyright= en-aut-name=YamaguchiYoshio en-aut-sei=Yamaguchi en-aut-mei=Yoshio kn-aut-name=山口義雄 kn-aut-sei=山口 kn-aut-mei=義雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=9 article-no= start-page=1429 end-page=1439 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fundamental and Clinical Studies on Medical Treatment of Moniliasis with Photosensitizing Dyes. Part. Ⅱ Biological trials on Treatment of Moniliasis with Photosensitizing dye NK 91 kn-title=感光色素によるモニリヤ症治療に関する基礎的並に臨床的研究 第2編 感光色素NK91号によるモニリヤ症治療に関する動物実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In vitro it was observed that NK 91 cxerted an excellent fungiostatic action against Candida albicans. So that, before clinical application, the author investigated about the fungiostatic action of NK 91 on experimental animals. The results were summarized as follows: 1) In the test of toxicity, mice which were given NK 91 subcutaneous injection over the certain quantity showed the symptoms of tachypnea and inactivity in the state of unrest and excitement and died finally. LD(50) in mice was 7.02 ± 0.38 mg/kg . 2) The hemolytic cation against the erythrocytes of rabbits occurred at the concentration of 5 γ / cc. It has been observed that the wandering velocity of neutrophils was moderate at the level of 1 γ / cc, slight accelerated at 10 γ / cc and slightly declined at 100 γ /cc. 3) The blood level of NK 91 in a non-oral administration maintained relatively high concentration in one to three hour, but declined rapidly with the lapse of time. 4) In respect of the protective test against the infection, it has been observed that the survival duration of experimental mice with Moniliasis were prolonged remarkably, compared with the control. 5) In therapeutic experiments, the author confirmed the remarkable decrease of Candida albicans in organs in the case treated with NK 91, compared with the control group in the case which was cultured from organs. Moreover, in the histologic investigations, the author observed the remarkable therapeutic effect in the treated group. en-copyright= kn-copyright= en-aut-name=YamaguchiYoshio en-aut-sei=Yamaguchi en-aut-mei=Yoshio kn-aut-name=山口義雄 kn-aut-sei=山口 kn-aut-mei=義雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=9 article-no= start-page=1441 end-page=1459 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fundamental and Clinical Studies on Medical Treatment of Moniliasis with Photosensitizing Dyes. Part. Ⅲ Clinical trials on treatment of Moniliasis with Photosensitizing dye NK 91 kn-title=感光色素によるモニリヤ症治療に関する基礎的並に臨床的研究 第3編 感光色素NK91号によるモニリヤ症治療に関する臨床実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=On the basis of the above mentioned examination, the author investigated the therapeutic effect of NK 91 against both tuberculosis and moniliasis patients discharging Candida albicans　continuously in sputum. 1) 241 cases (28.3%) of 850 patients with pulmonary tuberculosis, was dischaging Candida albicans in sputum. 2) The administration of NK 91 against tuberculosis patients discharging Candida ablicans in sputum, did nut present little appreciable changes against tuberculosis lesions, but remarkable decrease of Candida albicans in sputum. 3) In the administration of NK 91 to 6 patients with Moniliasis, three cases recovered completely and a case slightly, but others never. 4) Photosensitizing dye NK 91 showed a moderately fungiostatic activity as mentioned above. en-copyright= kn-copyright= en-aut-name=YamaguchiYoshio en-aut-sei=Yamaguchi en-aut-mei=Yoshio kn-aut-name=山口義雄 kn-aut-sei=山口 kn-aut-mei=義雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END