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ID 18587
Eprint ID
18587
FullText URL
Thumnail 72_1091.pdf 4.95 MB
Title Alternative
Anti-inflammatory Effect and Histamine-release Inhibitory Effect of Some Derivatives of Acetanilide and Pyrazolone
Author
Yamasaki, Hidemasa
Kondo, Kazuji
Uda, Teruo
Abstract
Three acetanilide and two pyrazolene derivatives were tested for anti-inflammatory effect on the edema of rat's hind-paws induced by the local injection of dextran, hyaluronidase, formaldehyde, histamine and 5-hydroxyptamine, and for histamine-release inhibitory effect on the rat receiving an intraperitoneal injection of ovomucoid which increases urinary output of histamine as a result of histamine release in the whole body. Phenacetin, acetanilide, aminopyrine, aminopropylone and butazolidine served as controls. GP-I, one of the pyrazolone derivatives (for formula cf. table 1), showed fairly marked supression on all 5 kinds of edema with effects comparable to aminopyrine and butazolidine. Acetanilide derivatives tested, also exerted marked inhibition on the edema other than by hyaluronidase or formaldehyde. All the compounds inhibited the histamine release due to ovomucoid injection, but no graded difference could be seen.
Published Date
1960-03-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume72
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1091
End Page
1096
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/72/4/72_4_1091/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma