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ID 17573
Eprint ID
17573
FullText URL
Thumnail 85_241.pdf 382 KB
Title Alternative
Immunological Surveillance System in the Course of Carcinogenesis after Administration of Methylcholanthrene to Mice
Author
Terada, Norihiko
Abstract
On the administration of methylcholanthrene (MCA) to mice there can be observed a decrease in the plaque forming cells (PFC) from early stage, and in the post-administration week 5, at the time considered to be of precancerous stage the decrease in PFC number is most marked, being at the minimal level of 55.6% as compared with that of the control (untreated mice). In other words, the administration of MCA reduces the PFC number of spleen cells in mice and it markedly suppresses the immunological activity of normal mice. This indicates that MCA is appreciably involved in the immunity to carcinogenesis. On the other hand, the activity of allogeneic inhibition in the precancerous stage is maintained during the period between MCA administration and the time of cancer development. However, the allogeneic inhibition activity decreases by 8 weeks after MCA administration, the time when the tumor has grown to the size macroscopically visible. This finding suggests that the activity of the allogeneic inhibition is associated more with the proliferation rather than with oncogenesis.
Published Date
1973-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
241
End Page
247
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/7-8/85_7-8_241/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma