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ID 14016
Eprint ID
14016
FullText URL
Thumnail 105_281.pdf 1.08 MB
Title Alternative
Leukocyte depletion reduced reperfusion injury in hearts preserved hypothermically for 6 hours
Author
Teraoka, Hiromichi
Abstract
Recent studies suggest that circulating leukocytes trapped in the post ischemic-reperfused organ release active oxygen species and leukotrienes, and cause tissue damage. Canine hearts statically preserved for six hours, were reperfused with whole blood (group Ⅰ, n=7), with leukocyte depleted blood (group Ⅱ, n=14), and with leukocyte and protein depleted blood (group Ⅲ, n=7). After initial perfusion, whole blood prefusion was started at 15 minutes of post reperfusion (group Ⅱa, n=7) and at 30 minutes of post reperfusion (group Ⅱb, n=7; group Ⅲ, n=7). Significant leukocytes sequestration wsa demonstrated only in group Ⅰ and group Ⅱa. Left ventricular function recovery, coronary flow and mitochondrial phospholyration activity were significantly better preserved in the groups reperfused with leukocyte depleted blood, especially gorup Ⅲ. These date suggest that leukocyte depletion amelioraes reperfusion injury of preserved hearts.
Keywords
再灌流障害
好中球集積
酸素フリーラジカル
Published Date
1993
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
281
End Page
289
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/3-4/105_3-4_281/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma