Author Chen, Ling| Kasai, Tomonari| Li, Yueguang| Sugii, Yuh| Jin, Guoliang| Okada, Masashi| Vaidyanath, Arun| Mizutani, Akifumi| Satoh, Ayano| Kudoh, Takayuki| Hendrix, Mary J. C.| Salomon, David S| Fu, Li| Seno, Masaharu|
Published Date 2012-04-12
Publication Title PLoS ONE
Volume volume7
Issue issue4
Content Type Journal Article
Author Shigehiro, Tsukasa| Kasai, Tomonari| Murakami, Masaharu| Sekhar, Sreeja C.| Tominaga, Yuki| Okada, Masashi| Kudoh, Takayuki| Mizutani, Akifumi| Murakami, Hiroshi| Salomon, David S.| Mikuni, Katsuhiko| Mandai, Tadakatsu| Hamada, Hiroki| Seno, Masaharu|
Published Date 2014-09-29
Publication Title PLoS ONE
Volume volume9
Issue issue9
Content Type Journal Article
JaLCDOI 10.18926/AMO/53521
FullText URL 69_3_145.pdf
Author Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi|
Abstract Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis.
Keywords ECP reactive oxygen species Akt ERK
Amo Type Original Article
Published Date 2015-06
Publication Title Acta Medica Okayama
Volume volume69
Issue issue3
Publisher Okayama University Medical School
Start Page 145
End Page 153
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26101190
Web of Science KeyUT 000356903000003
FullText URL cancers_11_2_177.pdf
Author Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi|
Keywords cancer stem cells combination therapy iron stemness
Published Date 2019-02-03
Publication Title Cancers
Volume volume11
Issue issue2
Publisher MDPI
Start Page 177
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors
File Version publisher
PubMed ID 30717462
DOI 10.3390/cancers11020177
Web of Science KeyUT 000460747200051
Related Url isVersionOf https://doi.org/10.3390/cancers11020177
FullText URL cancers11_3_2019.pdf
Author Afify, Said M.| Seno, Masaharu|
Keywords cancer stem cells cancer-inducing niche chronic inflammation induced pluripotent stem cells stem cell
Published Date 2019-03-11
Publication Title Cancers
Volume volume11
Issue issue3
Publisher MDPI
Start Page 345
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 30862050
DOI 10.3390/cancers11030345
Web of Science KeyUT 000468550200075
Related Url isVersionOf https://doi.org/10.3390/cancers11030345
FullText URL IJMS20_5_1042.pdf
Author Apriliana Cahya Khayrani| Mahmud, Hafizah| Zahra, Maram H.| Aung Ko Ko Oo| Oze, Miharu| Du, Juan| Alam, Md Jahangir| Afify, Said M.| Hagar A. Abu Quora| Shigehiro, Tsukasa| Anna Sanchez Calle| Okada, Nobuhiro| Seno, Akimasa| Fujita, Koki| Hamada, Hiroki| Seno, Yuhki| Mandai, Tadakatsu| Seno, Masaharu|
Keywords CD44 glycosylated paclitaxel liposome modified paclitaxel ovarian cancer specific targeting
Published Date 2019-02-27
Publication Title International Journal of Molecular Sciences
Volume volume20
Issue issue5
Publisher MDPI
Start Page 1042
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 30818864
DOI 10.3390/ijms20051042
Web of Science KeyUT 000462542300041
Related Url isVersionOf https://doi.org/10.3390/ijms20051042
FullText URL OL18_3_2756.pdf
Author Seno, Akimasa| Murakami, Chikae| El‑Aarag, Bishoy| Iwasaki, Yoshiaki| Ohara, Toshiaki| Seno, Masaharu|
Keywords cancer stem cell conditioned medium mouse embryonic stem cells
Published Date 2019-09
Publication Title Oncology Letters
Volume volume18
Issue issue3
Publisher Spandidos Publications
Start Page 2756
End Page 2762
ISSN 1792-1074
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © Seno et al.
File Version publisher
PubMed ID 31452753
DOI 10.3892/ol.2019.10614
Web of Science KeyUT 000487675500075
Related Url isVersionOf https://doi.org/10.3892/ol.2019.10614
FullText URL fulltext.pdf
Author Hassan, Ghmkin| Afify, Said M.| Nair, Neha| Kumon, Kazuki| Osman, Amira| Du, Juan| Mansour, Hager| Abu Quora, Hagar A.| Nawara, Hend M.| Satoh, Ayano| Zahra, Maram H.| Okada, Nobuhiro| Seno, Akimasa| Seno, Masaharu|
Keywords Induced pluripotent stem cells Cancer stem cells differentiation tumor microenvironment hematopoietic cells
Published Date 2019-12-29
Publication Title Cancers
Volume volume12
Issue issue1
Publisher MDPI
Start Page 82
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by the authors.
File Version publisher
PubMed ID 31905766
DOI 10.3390/cancers12010082
Web of Science KeyUT 000516826700082
Related Url isVersionOf https://doi.org/10.3390/cancers12010082
FullText URL fulltext.pdf
Author Osman, Amira| Afify, Said M.| Hassan, Ghmkin| Fu, Xiaoying| Seno, Akimasa| Seno, Masaharu|
Keywords CAFs TECs TAAs TAMs CSCs
Published Date 2020-04-04
Publication Title Cancers
Volume volume12
Issue issue4
Publisher MDPI
Start Page 879
ISSN 2072-6694
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32260363
DOI 10.3390/cancers12040879
Web of Science KeyUT 000535587400108
Related Url isVersionOf https://doi.org/10.3390/cancers12040879
FullText URL fulltext.pdf
Author Du, Juan| Seno, Akimasa| Sasada, Saki| Xu, Yanning| Oo, Aung Ko Ko| Hassan, Ghmkin| Ueno, Shunsuke| Afify, Said M.| Zahra, Maram H| Okada, Nobuhiro| Chen, Ling| Fu, Xiaoying| Tokutaka, Heizo| Yan, Ting| Seno, Masaharu|
Keywords miPSCs CSCs CCR6 CCL20
Published Date 2020
Publication Title Journal of Research in Medical and Dental Science
Volume volume8
Issue issue1
Publisher Amber Publication
Start Page 200
End Page 207
ISSN 2347-2367
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
Web of Science KeyUT 000518402400030
Related Url isVersionOf https://www.jrmds.in/abstract/upregulated-ccl20-and-ccr6-in-cancer-stem-cells-converted-from-mouse-ips-cells-52887.html