FullText URL fulltext.pdf
Author Tsuge, Mitsuru| Miyamoto, Machiko| Miyawaki, Reiji| Kondo, Yoichi| Tsukahara, Hirokazu|
Keywords Child Hemophagocytic lymphohistiocytosis Invasive pneumococcal disease Pneumococcal conjugate vaccine Serotype replacement
Published Date 2020-01-13
Publication Title BMC Pediatrics
Volume volume20
Issue issue1
Publisher BMC
ISSN 1471-2431
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 31931763
DOI 10.1186/s12887-020-1915-7
Web of Science KeyUT 000514577300003
Related Url isVersionOf https://doi.org/10.1186/s12887-020-1915-7
FullText URL fulltext.pdf fulltext2.pdf
Author Fujii, Yosuke| Yashiro, Masato| Yamada, Mutsuko| Kikkawa, Tomonobu| Nosaka, Nobuyuki| Saito, Yukie| Tsukahara, Kohei| Ikeda, Masanori| Morishima, Tsuneo| Tsukahara, Hirokazu|
Published Date 2018-03-14
Publication Title Disease Markers
Publisher Hindawi
Start Page 2380179
ISSN 0278-0240
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2018 Yosuke Fujii et al.
File Version publisher
PubMed ID 29725488
DOI 10.1155/2018/2380179
Web of Science KeyUT 000428395400001
Related Url isVersionOf https://doi.org/10.1155/2018/2380179
FullText URL fulltext.pdf
Author Knaup, Emily| Nosaka, Nobuyuki| Yorifuji, Takashi| Tsukahara, Kohei| Naitou, Hiromichi| Tsukahara, Hirokazu| Nakao, Atsunori| the JaRPAC Study Group|
Keywords Decision support Intensive care Length of stay Mortality Outcome Pediatric Risk Prediction rules Scoring system
Published Date 2019-07-29
Publication Title Journal of Intensive Care
Volume volume7
Publisher BMC
Start Page 38
ISSN 2052-0492
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s).
File Version publisher
PubMed ID 31384469
DOI 10.1186/s40560-019-0392-2
Web of Science KeyUT 000477892900001
Related Url isVersionOf https://doi.org/10.1186/s40560-019-0392-2
FullText URL CPE28_4_155.pdf
Author Hasegawa, Kosei| Ihoriya, Hiromi| Futagawa, Natsuko| Higuchi, Yousuke| Tsuchiya, Hiroki| Shibata, Takashi| Hayashi, Yumiko| Kobayashi, Katsuhiro| Tsukahara, Hirokazu|
Keywords developmental delay polyuria polydipsia fever poor weight gain
Note 本文データは学協会の許諾に基づきCiNiiから複製したものである|
Published Date 2019-10-19
Publication Title Clinical Pediatric Endocrinology
Volume volume28
Issue issue4
Publisher Japanese Society for Pediatric Endocrinology
Start Page 155
End Page 158
ISSN 0918-5739
NCID AA11006467
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders The Japanese Society for Pediatric Endocrinology
File Version publisher
PubMed ID 31666769
DOI 10.1297/cpe.28.155
Web of Science KeyUT 000491469300008
Related Url isVersionOf https://doi.org/10.1297/cpe.28.155
JaLCDOI 10.18926/AMO/54987
FullText URL 71_2_179.pdf
Author Nosaka, Nobuyuki| Tsukahara, Kohei| Knaup, Emily| Yabuuchi, Toshihiko| Kikkawa, Tomonobu| Fujii, Yosuke| Yashiro, Masato| Yasuhara, Takao| Okada, Ayumi| Ugawa, Toyomu| Nakao, Atsunori| Tsukahara, Hirokazu| Date, Isao|
Abstract Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management.
Keywords cerebral perfusion encephalopathy child intracranial pressure neurological intensive care
Amo Type Short Communication
Published Date 2017-04
Publication Title Acta Medica Okayama
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 179
End Page 180
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420900
Author Nosaka, Nobuyuki| Okada, Ayumi| Tsukahara, Hirokazu|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54819
JaLCDOI 10.18926/AMO/54805
FullText URL 70_6_435.pdf
Author Yamashita, Miho| Hasegawa, Kosei| Higuchi, Yousuke| Miyai, Takayuki| Okada, Ayumi| Tanaka, Hiroyuki| Tsukahara, Hirokazu|
Abstract The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p<0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p<0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
Keywords bone resorption marker bone turnover bone mass
Amo Type Original Article
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 435
End Page 439
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003667
FullText URL fulltext.pdf
Author Takahashi Nobumasa| Nojima, Ikuko| Araki, Tooru| Takasugi, Mizue| Sakane, Tomoko| Kodera, Aya| Ikeda, Masanori| Tsukahara, Hirokazu|
Keywords Norovirus false positive immunochromatography neonate rapid detection test specificity
Published Date 2015-09-03
Publication Title Journal of International Medical Research
Volume volume43
Issue issue5
Publisher Sage
Start Page 648
End Page 652
ISSN 0300-0605
NCID AA00700686
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 26338763
DOI 10.1177/0300060515592902
Web of Science KeyUT 000361592500006
Related Url isVersionOf https://doi.org/10.1177/0300060515592902
JaLCDOI 10.18926/AMO/54500
FullText URL 70_4_255.pdf
Author Nosaka, Nobuyuki| Fujiwara, Takeo| Knaup, Emily| Okada, Ayumi| Tsukahara, Hirokazu|
Abstract Estimation methods for pediatric weight have not been evaluated for Japanese children. This study aimed to assess the accuracy of mothersʼ reports of their childrenʼs weight in Japan. We also evaluated potential alternatives to the estimation of weight, including the Broselow tape (BT), Advanced Pediatric Life Support (APLS), and Parkʼs formulae. We prospectively collected cross-sectional data on a convenience sample of 237 children aged less than 10 years who presented to a general pediatric outpatient clinic with their mothers. Each weight estimation method was evaluated using Bland-Altman plots and by calculating the proportion within 10 and 20 of the measured weight. Mothersʼ reports of weight were the most accurate method, with 94.9 within 10 of the measured weight, the lowest mean difference (0.27kg), and the shortest 95 limit of agreement (-1.4 to 1.9kg). The BT was the most reliable alternative, followed by APLS and Parkʼs formulae. Mothersʼ reports of their children ʼs weight are more accurate than other weight estimation methods. When no report of a childʼs weight by the mother is available, BT is the best alternative. When an aged-based formula is the only option, the APLS formula is preferred.
Keywords body weight child estimation techniques mothers, parents
Amo Type Original Article
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 255
End Page 259
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549669
Web of Science KeyUT 000384748600004
Title Alternative Basic and clinical research regarding vascular endothelial function
FullText URL 127_187.pdf
Author Tsukahara, Hirokazu|
Keywords アルギニン代謝 一酸化窒素 ガス生物学 血管内皮学 酸化ストレス
Publication Title 岡山医学会雑誌
Published Date 2015-12-01
Volume volume127
Issue issue3
Start Page 187
End Page 195
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.187
NAID 130005116819
JaLCDOI 10.18926/AMO/53674
FullText URL 69_5_279.pdf
Author Saito, Yukie| Fujii, Yousuke| Yashiro, Masato| Tsuge, Mitsuru| Nosaka, Nobuyuki| Yamashita, Nobuko| Yamada, Mutsuko| Tsukahara, Hirokazu| Morishima, Tsuneo|
Abstract Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden chamber. After monolayer confluence was achieved, the culture media were replaced respectively by culture media containing edaravone, dexamethasone, and L-NMMA. After 24-h incubation, the monolayer was stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Fluorescein-labeled dextran was added. Then the trans-human PMVEC leak was measured. Expressions of vascular endothelial-cadherin (VE-cadherin) and zonula occludens-1 protein (ZO-1) were evaluated using real-time quantitative polymerase chain reaction and immunofluorescence microscopy. The results showed that TNF-α+IL-1β markedly increased pulmonary microvascular permeability. Pretreatment with edaravone, dexamethasone, or L-NMMA attenuated the hyperpermeability and inhibited the cytokine-induced reduction of VE-cadherin expression on immunofluorescence staining. Edaravone and dexamethasone increased the expression of ZO-1 at both the mRNA and protein levels. Edaravone and dexamethasone inhibited the permeability changes of human PMVEC, at least partly through an enhancement of VE-cadherin. Collectively, these results suggest a potential therapeutic approach for intervention in patients with ARDS.
Keywords pulmonary microvascular endothelial cells permeability edaravone vascular endothelial-cadherin zonula occludens-1 protein
Amo Type Original Article
Published Date 2015-10
Publication Title Acta Medica Okayama
Volume volume69
Issue issue5
Publisher Okayama University Medical School
Start Page 279
End Page 290
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26490025
Web of Science KeyUT 000365519600004