JaLCDOI 10.18926/fest/11514
Title Alternative Preparation of Biodegradable Polymer Microcapsules Enclosing Anti-mite Agent
FullText URL 008_103_106.pdf
Author Minobe, Kouichi| Yoshizawa, Hidekazu| Kitamura, Yoshiro|
Abstract Many kinds of mite was caused by allergy and sick house syndrome, so it has become one of the social problems. Farnesyl acetone is one of the most potent anti-mite agent. However the vapor pressure of farnesyl acetone is high even at room temperature. This indicates the anti-mite effect has not been sustained even though the agent has strong anti-mite effect. In this study, we attempted to prepare polylactide microcapsule with farnesyl acetone for the purpose of sustainable dosage form of anti-mite agent. Microcapsule was prepared by solvent evaporation, which was a method of microencapsulation. The effects of preparation conditions on the enclosing efficiency, the release of microcapsule and anti-mite effect of microcapsule were investigated.
Keywords farnesyl acetone anti-mite effect polylactide microcapsule solvent evaporation
Publication Title 岡山大学環境理工学部研究報告
Published Date 2003-03
Volume volume8
Issue issue1
Start Page 103
End Page 106
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002314003
JaLCDOI 10.18926/fest/11513
Title Alternative Decontamination of Waste-water by Metal Phthalocyanines Encapsulated in Polymeric Microcapsules
FullText URL 008_097_101.pdf
Author Takami, Koji| Yoshizawa, Hidekazu| Sakata, Isao| Kitamura, Yoshiro|
Abstract Polymeric microcapsules encapsulating iron phthalocyanine (Fe-Pc) and zinc phthalocyanine (Zn-Pc) were successfully prepared in this study. Absorption spectra of polymeric microcapsules encapsulating metal phthalocyanines were measured in visible light range. It was expected from the results that the polymeric microcapsules encapsulating metal phthalocyanines showed high photocatalytic activity upon irradiation with visible light such as sunlight. The catalytic and phtocatalytic activities of encapsulated Fe-Pc and Zn-Pc were investigated in the decomposition of methylene blue in water. The encapsulatedd Fe-Pc with H(2)O(2) exhibited a high catalytic activity. Methlene blue was efficiently decomposed by interaction of Fe-Pc with H(2)O(2).
Keywords microcapsule decomposition metal phthalocyanine waste-water treatment suspension polymerizatio
Publication Title 岡山大学環境理工学部研究報告
Published Date 2003-03
Volume volume8
Issue issue1
Start Page 97
End Page 101
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313830
JaLCDOI 10.18926/fest/11540
Title Alternative Formation of Crosslinked Polyurea Membrane by Phase Separation Method
FullText URL 006_099_102.pdf
Author Kobayashi, Eiji| Yoshizawa, Hidekazu| Jacobson Joseph| Kitamura, Yoshiro|
Abstract This research was conducted to clarify the membrane formation mechanism of crosslinked polyurea microcapsules by phase separation method, specially the role of polymeric surfactant of poly(ethylene-alt-maleic anhydride),(poly(E-MA))at the interface of O/W emulsion. Because of its toxicity, alternative chemicals should be chosen. This understanding may make possible to find the alternative chemicals. It was found that poly(E-MA)was necessary for the formation of crosslinked polyurea membrane. The addition of sodium dodecyl sulfate (SDS) prohibited the membrane formation reaction at the interface, even in the care of poly(E-MA) concentration enough for polymeric microcapsule formation. From the results in this study, poly(E-MA) as polymeric surfactant was found to be adsorbed on the interface of O/W emulsion and provide the reaction site for the membrane formation of polymeric microcapsules.
Keywords microcapsulation O/W emulsion polyurea polymeric surfactant
Publication Title 岡山大学環境理工学部研究報告
Published Date 2001-02-28
Volume volume6
Issue issue1
Start Page 99
End Page 102
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313844
JaLCDOI 10.18926/fest/11543
Title Alternative Fertilizer Microencapsulated with Biodegradable Polymer
FullText URL 007_127_131.pdf
Author Futaki, Sakae| Yoshizawa, Hidekazu| Matsuo, Mitsunori| Kusumoto, Masahiko| Kitamura, Yoshiro|
Abstract Many fertilizers are soluble in water, therefore their effect does not last for long time after fertilizing in soils. The nitrogenous fertilizers such as urea transported to groundwater cause serious agricultural contamination and health problems. To solve these problems, sustained release of fertilizer has attracted much attention. In this study, we attempted to prepare polylactide microcapsules with fertilizer by phase separation technique, which was a method of microencapsulation. Polylactide (PLA) was used as a biodegradable polymer bacause the biodegradable polymer has no influence on the soil and the ecosystem. The effect of preparation conditions such as stirring time and fertilizer concentration on morphology of microcapsule and on cumulative percentage released of enclosed urea was also investigated.
Keywords fertilizer polylactide microcapsule controlled release phase separation
Publication Title 岡山大学環境理工学部研究報告
Published Date 2002-03-22
Volume volume7
Issue issue1
Start Page 127
End Page 131
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313894
JaLCDOI 10.18926/fest/11542
Title Alternative Preparation and In Vitro Release Property of PLA Microspheres Enclosing Antitumor Agent
FullText URL 006_103_106.pdf
Author Nishino, Satoru| Yoshizawa, Hidekazu| Natsugoe, Shoji| Aiko, Takashi| Hatate, Yasuo| Kitamura, Yoshiro|
Abstract Recently, many antitumor agents developed. Irinotecan hycrochloride (CPT) has a great side effect even though it is well effective against the cancer. Drug delivery system (DDS) medicine indicates that the release rate of medicine is constant for a long time. Therefore, in order to materialize the general idea of DDS, we applied microencapsulation technique to prepare biodegradable polymer microspheres (MS) enclosing antitumor drug having no side effect. Polylactide microparticles enclosing antitumor agent were prepared by solvent evaporation method under various operation conditions. The effects of operation parameter on release rate of drug and morphology of microparticles were studied.
Keywords DDS microparticle polylactide antitumor agent solvent evaporation DSC
Publication Title 岡山大学環境理工学部研究報告
Published Date 2001-02-28
Volume volume6
Issue issue1
Start Page 103
End Page 106
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002314051
JaLCDOI 10.18926/fest/11445
Title Alternative Emulsification Properties of Poly(lactide-block-ethylene glycol-block-lacticide) Block Polymers
FullText URL 011_107_110.pdf
Author Matsumoto, Yasuo| Kitamura, Yoshiro| Yoshizawa, Hidekazu|
Abstract Homo-and copolymers of poly(lactic acid) have gathered much attention because of their biodegradability and biocompatibility. They have numerous applications in the biomedical field due to their potential. In their polymers, we are interested in poly(lactic acid)-poly(ethylene glycol) block polymers. The amphiphilic triblock copolymers, poly(DL-lactic acid)-poly(ethylene glycol)-poly(DL-lactic acid)(PLEL), have known to be surface-active ability. Therefore, we have studied emulsification properties with the polymers. PLEL were prepared by ring-opening copolymerization of DL-lactide and poly(ethylene glycol) catalyzed by stannous 2-ethylhexanoate. We prepared ethyl acetate-water-PLEL emulsion and applied this emulsion to biodegradable polymer scaffolds. PLA scaffolds were prepared by an emulsion freeze-drying method. These scaffolds were made by varying water weight fraction. Their surface pore size became larger with increasing water weight fraction.
Keywords Poly(lactic acid) Poly(ethylene glycol) Biodegradable polymer Tissue Engineering Surfactant
Publication Title 岡山大学環境理工学部研究報告
Published Date 2006-03-15
Volume volume11
Issue issue1
Start Page 107
End Page 110
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002314040
JaLCDOI 10.18926/fest/11444
Title Alternative Synthesis of Novel Temperature-responsive Polymer Gel of Poly(aspartic acid)s
FullText URL 011_103_106.pdf
Author Uehara, Hiroki| Tanimoto, Fumiaki| Kitamura, Yoshiro| Yoshizawa, Hidekazu|
Abstract Recently, thermo-responsive polymer gels have been studied in various research fields such as drug delivery system. One of represetative thermo-responsive polymer gels is poly(N-isopropylacrylamide) gel (PNIPAAm) that has a rapid and reversible volume phase transition. However, PNIPAAm is not biodegradable, resulting in limitation of its use in medical fields. Novel thermo-responsive polymer gel was prepared by closslinking of isopropylamine modified poly(succinimide) (IPA-PSI) (Poly[α,β -(DL-aspartate isopropyl amide)-co-(succinimide)]) with hexamethylenediamine. Because of peptide bonds in backbone, therefore, it is expected to possess biodegradability and biocompatibility. These gels changed their volume in response to change of environment such as temperature, pH and concentration of salt in water. Crosslinkage density and substitution degree of IPA-PSI affected volume phase transition bahavior of the gel.
Keywords Thermo-responsive polymer gel Biodegradable polymer Poly(aspartic acid) Lower Critical Solution Temperature(LCST) Drug delivery system(DDS)
Publication Title 岡山大学環境理工学部研究報告
Published Date 2006-03-15
Volume volume11
Issue issue1
Start Page 103
End Page 106
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313620
JaLCDOI 10.18926/fest/11647
FullText URL 001_211_219.pdf
Author Kitamura, Yoshiro| Ohta, Tomoyuki|
Abstract The drop formation in immiscible liquid-liquid systems under mass transfer conditions was experimentally investigated. To know the exact effact effect of mass transfer on drop sizes, the decrease of interfacial tensions due to the presence of solutes has to be evaluate. Interfacial tensions of liquid pairs were measured with a Wilhelmy method as a function of the relative amounts at which both the solution and the solvent were mutually saturated. The interfacial tensions between the liquid pairs mutually saturated at on equal amount were found to be appropriate for the prediction of the drop formation accompanying mass transfer.
Keywords Interfacial tension Drop size Extraction Mass transfer
Publication Title 岡山大学環境理工学部研究報告
Published Date 1996-03
Volume volume1
Issue issue1
Start Page 211
End Page 219
ISSN 1341-9099
language 英語
File Version publisher
NAID 120002313573