JaLCDOI 10.18926/AMO/54981
FullText URL 71_2_127.pdf
Author Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi|
Abstract Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified.
Keywords esophageal cancer radiation therapy high-risk patient
Amo Type Original Article
Published Date 2017-04
Publication Title Acta Medica Okayama
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 127
End Page 133
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420894
Author Waki, Takahiro| Katsui, Kuniaki| Mitsuhashi, Toshiharu| Ogata, Takeshi| Katayama, Norihisa| Takemoto, Mitsuhiro| Nasu, Yasutomo| Kumon, Hiromi| Kanazawa, Susumu|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54823
JaLCDOI 10.18926/AMO/53554
FullText URL 69_4_189.pdf
Author Yamashita, Mako| Katayama, Norihisa| Waki, Takahiro| Katsui, Kuniaki| Himei, Kengo| Takemoto, Mitsuhiro| Kanazawa, Susumu|
Abstract This study compared field-in-field (FIF) radiotherapy with conformal radiotherapy with physical wedges for the treatment of unilateral cervical malignant lymphoma. Two treatment plans, the FIF technique and conformal RT, were generated for each of 32 patients with unilateral cervical malignant lymphoma. To compare the 2 treatment plans, dose-volume histograms of the planning target volume (PTV), the thyroid, submandibular gland, carotid artery, mucosa, spinal cord, and surrounding normal tissue, and monitor unit (MU) were analyzed. The FIF technique showed significant reduction in the mean dose of thyroid, submandibular gland, carotid artery and mucosa, the maximum dose of the spinal cord and PTV, and the volume receiving>107% of the prescribed dose of surrounding normal tissue (p<0.001). In addition, there were gains in the homogeneity index of the PTV for FIF. Furthermore, the total MU was also lower for the FIF technique than for the wedge technique (p<0.001). Compared with the wedge technique, the FIF technique improved the dose homogeneity of the PTV, reduced the dose to normal structures, and was associated with fewer MUs in the treatment of patients with cervical malignant lymphoma.
Keywords field-in-field technique wedge lymphoma monitor units dose-volume histogram
Amo Type Original Article
Published Date 2015-08
Publication Title Acta Medica Okayama
Volume volume69
Issue issue4
Publisher Okayama University Medical School
Start Page 189
End Page 195
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26289909
Web of Sience KeyUT 000365519100001
Sort Key 14
Title Alternative Proton therapy
FullText URL 127_155.pdf
Author Katsui, Kuniaki| Okimoto, Tomoaki| Kanazawa, Susumu|
Note キーワード(Key Word)
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Publisher 岡山医学会
Publisher Alternative Okayama Medical Association
Start Page 155
End Page 157
ISSN 0030-1558
NCID AN00032489
Content Type Article
Related Url isVersionOf https://doi.org/10.4044/joma.127.155
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
Refereed True
DOI 10.4044/joma.127.155
NAID 130005096259
Eprints Journal Name joma
References 1) Demizu Y, Fujii O, Terashima K, Mima M, Hashimoto N, Niwa Y, Akagi T, Daimon T, Murakami M, Fuwa N : Particle therapy for mucosal melanoma of the head and neck. A single-institution retrospective comparison of proton and carbon ion therapy. Strahlenther Onkol (2014) 190, 186-191. 2) Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Sasaki R, Hori Y, Hishikawa Y, Ku Y, Murakami M : Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma. Cancer (2011) 117, 4890-4904. 3) Miralbell R, Lomax A, Cella L, Schneider U : Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys (2002) 54, 824-829. 4) Merchant TE, Kiehna EN, Li C, Shukla H, Sengupta S, Xiong X, Gajjar A, Mulhern RK : Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma. Int J Radiat Oncol Biol Phys (2006) 65, 210-221. 5) Hoppe BS, Flampouri S, Zaiden R, Slayton W, Sandler E, Ozdemir S, Dang NH, Lynch JW, Li Z, Morris CG, Mendenhall NP : Involved-node proton therapy in combined modality therapy for Hodgkin lymphoma : results of a phase 2 study. Int J Radiat Oncol Biol Phys (2014) 89, 1053-1059. 6) Chang JY, Zhang X, Wang X, Kang Y, Riley B, Bilton S, Mohan R, Komaki R, Cox JD : Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys (2006) 65, 1087-1096. 7) Chang JY, Komaki R, Lu C, Wen HY, Allen PK, Tsao A, Gillin M, Mohan R, Cox JD : Phase 2 study of high-dose proton therapy with concurrent chemotherapy for unresectable stage III nonsmall cell lung cancer. Cancer (2011) 117, 4707-4013.
Author Harada, Sosuke| Takemoto, Mitsuhiro| Yoshio, Koutarou| Kojima, Katsuhide| Katayama, Norihisa| Katsui, Kuniaki| Kuroda, Masahiro| Matsuo, Toshihiko| Kanazawa, Susumu|
Published Date 2010-12-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/31983
FullText URL fulltext.pdf
Author Fujie, Shunji| Okumura, Yoshihiro| Sato, Shuhei| Akaki, Shiro| Katsui, Kuniaki| Himei, Kengo| Takemoto, Mitsuhiro| Kanazawa, Susumu|
Abstract <p>We investigated the diagnostic capabilities of I-131, Tl-201, and Tc-99m-MIBI (hexakis-2-methoxyisobutyl- isonitrile) scintigraphy for thyroid cancer metastases after total thyroidectomy over the entire body and for every locus before and after thyroid bed ablation. After total thyroidectomy of thyroid cancer, 36 cases were subjected to I-131 treatment 64 times. They consisted of 17 men and 19 women with 31 papillary carcinomas and 5 follicular carcinomas. Their ages were 22--75(an average of 60.5+/-12.3) years. I-131 scintigraphy(I-131), Tl-201 scintigraphy(Tl-201), and Tc-99m- MIBI scintigraphy (Tc-99m-MIBI) were performed. We defined the metastases as those cases in which serum thyroglobulin (Tg)increased significantly or in which we were able to prove the lesions on CT (computed tomography), MRI (magnetic resonance imaging) or bone scintigram. Three radiology medical specialists visually evaluated each scintigram and calculated the sensitivity, specificity, and likelihood ratio. For whole-body sensitivity, both Tl-201 and Tc-99m-MIBI were high before ablation and I-131 was high after ablation. Before ablation, the negative likelihood ratio was less than 0.1 for Tl-201 and Tc-99m-MIBI, while the positive likelihood ratio was more than 10 for Tl-201. After ablation, the positive likelihood ratio for I-131, Tl-201, and Tc-99m-MIBI was more than 10. The sensitivity of the mediastinum was appropriate, except for I-131 before ablation, and the sensitivity of the lung before and after ablation was inferior for either tracer. The specificity of the cervix for I-131 before ablation was markedly deteriorated, but it increased after ablation.</p>
Keywords I-131scintigraphy Tl-201 scintigraphy Tc-99m-MIBI scintigraphy thyroid cancer metastases
Amo Type Article
Published Date 2005-06
Publication Title Acta Medica Okayama
Volume volume59
Issue issue3
Publisher Okayama University Medical School
Start Page 99
End Page 107
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16049563
Web of Sience KeyUT 000230039100005
Author Katsui, Kuniaki| Takemoto, Mitsuhiro| Kanazawa, Susumu|
Published Date 2009-12-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue3
Content Type Journal Article
Author Ichihara, Eiki| Matsuoka, Junji| Takigawa, Nagio| Matsuzaki, Takashi| Katsui, Kuniaki| Kiura, Katsuyuki| Tanimoto, Mitsune|
Published Date 2009-12-01
Publication Title 岡山医学会雑誌
Volume volume121
Issue issue3
Content Type Journal Article
Author Takemoto, Mitsuhiro| Katayama, Norihisa| Katsui, Kuniaki| Kanazawa, Susumu|
Published Date 2008-12-01
Publication Title 岡山医学会雑誌
Volume volume120
Issue issue3
Content Type Journal Article