Author Kikuchi, Hiroshi| Shiozawa, Nobuyoshi| Takata, Shingo| Ashida, Kozo| Mitsunobu, Fumihiro|
Published Date 2013-12-12
Publication Title International Journal of Chronic Obstructive Pulmonary Disease
Volume volume9
Content Type Journal Article
Author Yamaoka, Kiyonori| Mitsunobu, Fumihiro| Kojima, Shuji| Shibakura, Misako| Kataoka, Takahiro| Hanamoto, Katsumi| Tanizaki, Yoshiro|
Published Date 2005-04-01
Publication Title Journal of Radiation Research
Volume volume46
Issue issue1
Content Type Journal Article
Author Kataoka, Takahiro| Sakoda, Akihiro| Ishimori, Yuu| Toyota, Teruaki| Nishiyama, Yuichi| Tanaka, Hiroshi| Mitsunobu, Fumihiro| Yamaoka, Kiyonori|
Published Date 2011-11-22
Publication Title Journal of Radiation Research
Volume volume52
Issue issue6
Content Type Journal Article
JaLCDOI 10.18926/AMO/32675
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ochi, Koji| Harada, Hideo| Kimura, Ikuro|
Abstract The improvement of ventilatory function by spa therapy was examined in 37 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. All subjects had been on long-term corticosteroid therapy before spa therapy. Spa therapy was found to improve the values of ventilatory parameters. The percent improvement in all subjects was +4.1% in %FVC, +8.9% in FEV1.0%, +9.8% in %PEFR, +22.0% in %MMF, +19.7% in %V50 and +28.2% in %V25, respectively. Relating to clinical asthma types, moderate improvement in %MMF and %V25 from 16.7% to 16.9% was observed in type Ia cases, and marked increase in %MMF, %V50 and %V25 was observed from 42.2% to 43.2% in type Ib cases. However, no significant increase was found in these parameters of types Ia or Ib after spa therapy. In patients with type II, a significant increase was shown in %V50 (p less than 0.05) and %V25 (p less than 0.01) after spa therapy. The results show that spa therapy improves the condition of small airways disorder in patients with SDIA.
Keywords spa therapy bronchial asthma ventilatory function small airways
Amo Type Article
Published Date 1992-06
Publication Title Acta Medica Okayama
Volume volume46
Issue issue3
Publisher Okayama University Medical School
Start Page 175
End Page 178
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1502922
Web of Sience KeyUT A1992JB50400005
JaLCDOI 10.18926/AMO/32659
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Honke, Naoko| Kusaura, Yasuharu| Kimura, Ikuro|
Abstract <p>Bronchial asthma was classified by the pathophysiology and by the mechanism of onset of the disease. Forty asthmatics who had serum IgE levels lower than 200 IU/ml were evaluated by two classification methods. 1. In asthma classified by a score based on clinical findings and examinations, the characteristics of the findings and examination results were compared among three asthma types, i.e., Ia. simple broncho-constriction type, Ib. bronchoconstriction+hypersecretion type, and II. bronchiolar obstruction type. Type Ib patients, in addition to manifesting hypersecretion, had a significantly higher proportion of eosinophils in the bronchoalveolar lavage (BAL) fluid compared to other asthma types. Significantly decreased values for ventilatory parameters and an increased proportion of BAL neutrophils were found in type II compared with other asthma types. 2. In a new classification by mechanism of onset, asthma was classified into three types according to the degree of participation of IgE-mediated reactions associated with specific IgE antibodies and serum levels of total IgE: asthma induced by definite IgE-mediated reaction (atopic asthma), possible IgE-mediated reactions (asthma), and asthma induced by non-IgE-mediated reaction (asthma syndrome).</p>
Keywords asthma asthma syndrome classification by pathophysiology classification by mechanism of onset
Amo Type Article
Published Date 1992-10
Publication Title Acta Medica Okayama
Volume volume46
Issue issue5
Publisher Okayama University Medical School
Start Page 381
End Page 387
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1442158
Web of Sience KeyUT A1992JX49500009
JaLCDOI 10.18926/AMO/32622
FullText URL fulltext.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Ochi, Koji| Harada, Hideo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract Twenty-one patients with atopic asthma were classified into three types according to their symptoms (clinical diagnosis): Ia, simple bronchoconstriction; Ib, bronchoconstriction + hypersecretion; and II, bronchiolar obstruction, and this classification was compared with a classification made according to clinical findings and examinations (score diagnosis). Type Ib asthma was characterized by the increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF), while type II was characterized by ventilatory dysfunction in small airways and the increased incidence of neutrophils in BALF. Four patients, whose expectoration was between 50 and 99ml/day, of the 12 with type Ia assessed by clinical diagnosis were evaluated as type Ib by score diagnosis. One patient with type II by clinical diagnosis was assessed as questionable type II by score diagnosis. In the other 16 patients, the clinical and score diagnoses were the same.
Keywords bronchial asthma classification ventilatory function cellular composition of BALF sore diagnosis
Amo Type Article
Published Date 1992-08
Publication Title Acta Medica Okayama
Volume volume46
Issue issue4
Publisher Okayama University Medical School
Start Page 295
End Page 301
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1442153
Web of Sience KeyUT A1992JL44200010
JaLCDOI 10.18926/AMO/32167
FullText URL fulltext.pdf
Author Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Asaumi, Noboru| Tanizaki, Yoshiro| Harada, Hideo| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract <p>Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in specific IgG4 was dependent on the total dose of house dust administered in both children (r = 0.636, p less than 0.001) and adults (r = 0.629, p less than 0.01). However, the increase of specific IgG4 in adults was not as apparent as in children. These results might suggest that mite specific IgG4 is a useful immunological marker in the immunotherapy for allergic asthma, and that IgG4 antibody acts as a blocking antibody in atopic bronchial asthma.</p>
Keywords house dust mite bronchial asthma hyposensitization specific IgG4
Amo Type Article
Published Date 1991-08
Publication Title Acta Medica Okayama
Volume volume45
Issue issue4
Publisher Okayama University Medical School
Start Page 267
End Page 273
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1962533
Web of Sience KeyUT A1991GD78000009
JaLCDOI 10.18926/AMO/31587
FullText URL fulltext.pdf
Author Kitani, Hikaru| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Mifune, Takashi| Mitsunobu, Fumihiro| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Tanizaki, Yoshiro|
Abstract <p>Immunoallergological studies were carried out to clarify the differences between 24 patients with drug-induced asthma (DIA) and 240 with non-drug-induced asthma (non-DIA). The mean values of age, skin reaction to Candida albicans (C. albicans), serum IgE levels, specific IgE antibodies to house dust (HD) and C. albicans, bronchial sensitivity and leukotriene B4 (LTB4) synthesis from peripheral venous blood in patients with DIA were not significantly different from those in patients with non-DIA. In contrast, the frequency of positive skin reaction to HD and histamine release from peripheral basophils by anti-IgE were significantly lower in DIA than in non-DIA. These results agree with the reports that DIA was often observed in non-atopic asthma. But, the mean value of serum IgE was very high in DIA as well as in non-DIA. This result suggests that IgE mediated reaction in DIA is important. Furthermore, the proportion of neutrophils in bronchoalveolar lavage fluid (BALF) was significantly lower in DIA than in non-DIA. Our findings suggest that a decrease of intrapulmonary neutrophils might play an important role in the pathophysiology of DIA.</p>
Keywords drug allergy aspirin-induced asthma. LgE-mediated reacion chemical mediator bronchoalveolar lavage
Amo Type Article
Published Date 1993-10
Publication Title Acta Medica Okayama
Volume volume47
Issue issue5
Publisher Okayama University Medical School
Start Page 317
End Page 321
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7505995
Web of Sience KeyUT A1993ME47100005
JaLCDOI 10.18926/AMO/31578
FullText URL fulltext.pdf
Author Mifune, Takashi| Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Kimura, Ikuro|
Abstract <p>The effects of long-term glucocorticoid therapy on chemical mediator and cellular reaction in the airways were examined in 69 patients with bronchial asthma. The histamine release induced by Ca ionophore A23187 from cells in the bronchoalveolar lavage (BAL) fluid of atopic asthmatics was significantly lower in the subgroup with steroid-dependent intractable asthma (SDIA) than in non-SDIA patients (p &#60; 0.05). In contrast, histamine release in nonatopic SDIA patients did not differ from nonatopic non-SDIA patients. The release of leukotriene C4 (LTC4) was significantly lower in atopic patients with SDIA (p &#60; 0.02). However, there was no significant difference in LTC4 release between nonatopic patients with SDIA and without SDIA. The proportion of BAL lymphocytes was significantly lower in atopic patients with SDIA than in those without it (p &#60; 0.05), although there was no significant difference between the nonatopic patients with and without SDIA. These results show that glucocorticoids affect humoral and cellular events in the airways of atopic asthmatics more than in those of nonatopic asthmatics.</p>
Keywords histamine leukotrienes BAL cells intractable asthma glucocorticoids
Amo Type Article
Published Date 1993-10
Publication Title Acta Medica Okayama
Volume volume47
Issue issue5
Publisher Okayama University Medical School
Start Page 323
End Page 328
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7505996
Web of Sience KeyUT A1993ME47100006
JaLCDOI 10.18926/AMO/31550
FullText URL fulltext.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Okano, Tomoharu| Honke, Naoko| Tanizaki, Yoshiro|
Abstract <p>Cell-mediated immunity was examined in 45 patients with bronchial asthma by observing the delayed cutaneous reaction to purified protein derivative (PPD) and Candida albicans (C. albicans). The delayed skin reaction to PPD showed a decrease with age starting between 50 and 59 years old. The delayed reaction to PPD decreased more prominently with aging, being significantly depressed in the patients aged over 70 years than in those aged between 30 and 49 years (induration, p &#60; 0.02; flare, p &#60; 0.01). The C. albicans-induced skin reaction was significantly lower in the patients aged over 70 years than in those between 60 and 69 years old (induration, p &#60; 0.01; flare, p &#60; 0.05). The delayed skin reaction to PPD and C. albicans was significantly depressed in the patients with a serum IgE level over 1001 IU/ml. Delayed skin reaction to PPD and C. albicans was more depressed with aging and an elevated serum IgE, and the age (50-59 years) at the initiation of depression in the PPD-induced delayed skin reaction was younger than that (over 70 years) in the C. albicans-induced reaction.</p>
Keywords cell-mediated immunity PPD Candida albicans bronchial asthma
Amo Type Article
Published Date 1993-08
Publication Title Acta Medica Okayama
Volume volume47
Issue issue4
Publisher Okayama University Medical School
Start Page 229
End Page 232
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8213216
Web of Sience KeyUT A1993LV73800002
Author Mitsunobu, Fumihiro|
Published Date 1988
Publication Title 岡山医学会雑誌
Volume volume100
Issue issue5-6
Content Type Journal Article
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro|
Published Date 1994-09
Publication Title 岡大三朝分院研究報告
Volume volume65
Content Type Departmental Bulletin Paper
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Tanizaki, Yoshiro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Departmental Bulletin Paper
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Departmental Bulletin Paper
Author Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Departmental Bulletin Paper
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke|
Published Date 1993-06
Publication Title 岡大三朝分院研究報告
Volume volume64
Content Type Departmental Bulletin Paper
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro|
Published Date 1993-06
Publication Title 岡大三朝分院研究報告
Volume volume64
Content Type Departmental Bulletin Paper
Author Kitani, Hikaru| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Departmental Bulletin Paper
Author Ochi, Koji| Miyake, Hirofumi| Matsumoto, Shuji| Seno, Toshinobu| Tanaka, Juntaro| Harada, Hideo| Mitsunobu, Fumihiro| Tanizaki, Yosiro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Departmental Bulletin Paper
Author Tanizaki, Yosiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Harada, Hideo| Ochi, Koji| Kimura, Ikuro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Departmental Bulletin Paper