JaLCDOI 10.18926/AMO/30946
FullText URL fulltext.pdf
Author Kilciksiz, Sevil| Demirel, Can| Erdal, Nurten| Gürgül, Serkan| Tamer, Lülüfer| Ayaz, Lokman| Örs, Yasemin|
Abstract <p>Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparing its biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors, in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and equally into 4 groups:Control (C), Radiation (R), R+NAC (received irradiation and 1,000mg/kg NAC) and R&#65291;WR-2721 (received irradiation and 200mg/kg WR-2721) rats. Liver tissues and blood samples were harvested and utilized for reduced glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) detection. Serum and tissue GSH levels of R rats decreased compared to those of other groups (p&#60;0.01). Tissue MDA levels of R+NAC and R+WR-2721 rats decreased compared to R rats (p&#60;0.01;p&#60;0.05, respectively). Tissue MPO activities of R+NAC and R+WR-2721 rats were higher than those of R rats (p&#60;0.001). Serum MPO levels of R+WR-2721 rats were lower than those of C rats and R rats (p&#60;0.01, p&#60;0.001, respectively). In conclusion, the study suggests that the radioprotective effect against radiation-induced oxidative damage of NAC may be similar to that of WR-2721.</p>
Keywords irradiation-injury N-acetylcysteine WR-2721
Amo Type Original Article
Published Date 2008-12
Publication Title Acta Medica Okayama
Volume volume62
Issue issue6
Publisher Okayama University Medical School
Start Page 403
End Page 409
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Science KeyUT 000262025000007