Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Type Ⅱ (bronchiolar obstruction) asthma and number of neutrophils in bronchoalveolar lavage (BAL) fluid

Tanizaki, Yoshiro
Mifune, Takashi
Hosaki, Yasuhiro
Yokota, Satoshi
Tsugeno, Hirofumi
Takeuchi, Kazuaki
Nawa, Yuichiro
Ochi, Koji
Harada, Hideo
Taketa, Kazuhisa
Abstract
Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type Ⅱ, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type Ⅱ, bronchiolar obstruction, asthma. However, there are some type Ⅱ asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type Ⅱ asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging.
Keywords
Asthma classification (喘息分類)
BAL lymphocytes (BALリンパ球)
BAL neutrophils (BAL好中球)
% V25 value
Ⅱ型喘息
ISSN
0918-7839
NCID
AN10430852