Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

Some items are not available because of decision by its author or publisher.

Difference in motility of basophilic, granulocytes from atopic subjects following antigen- and Ca inophore A23187-stimulation

Tanizaki, Yoshiro
Kitani, Hikaru
Mifune, Takashi
Mitsunobu, Fumihiro Kaken ID publons researchmap
Ochi, Koji
Harada, Hideo
Nakagawa, Saburo
Soda, Ryo
Kimura, Ikuro
We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells.
histamine release (ヒスタミン遊離)
increased basophil motility (好塩基球の運動能の亢進)
bridging of IgE receptors (LgE 受容体)
antigen (抗原)
Ca ionophore A23187