Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

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岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Immunosuppression by glucocorticoids leads to bronchoalveolar neutrophilia in patients with bronchial asthma

Tanizaki, Yoshiro
Kitani, Hikaru
Mifune, Takashi
Kajimoto, Kazuhiro
Sugimoto, Keisuke
Yokota, Satoshi
Hiramatsu, Junichi
Kawaraya, Masashi
Harada, Hideo
Kimura, Ikuro
Abstract
Cellular composition of bronchoalveolar lavage (BAL) fluid was compared between two age-matched steroid-dependent intractable asthma (SDIA) groups : 17 group A patients (serum IgG level < 1000mg/dℓ) whose immunity was regarded as being suppressed by long-term glucocorticoid therapy and 17 group B patients (serum IgG level > 1200mg/dℓ). 1. The levels of serum IgA and IgM were significantly decreased in group A compared to the levels in group B patients. 2. The number of blood lymphocytes was also significantly lower in group A than in group B patients. However, the number of blood neutrophils was not different between the two asthma groups. 3.The number of BAL lymphocytes was significantly lower in group A than in group B patients. 4. BAL neutrophilia (more than 1.5×10 (4)/mℓ) was observed in 6 of the 17(35.3%) patients in group A, but not observed in any patients in group B. The number of BAL neutrophils was significantly greater in group A than in group B patients. These results suggest that there is a correlation between immunosuppression by glucocorticoids and BAL neutrophilia in patients with bronchial asthma.
Keywords
immunosuppression (免疫抑制)
BAL neutrophilia (BAL好中球増多)
glucocorticoids (副腎皮質ホルモン)
bronchial asthma (気管支喘息)
ISSN
0918-7839
NCID
AN10430852