Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Transferrin-Mediated Cellular Iron Uptake -Special Implication of Endothelium in Hepatic Iron Uptake-

Irie, Seiji
Matsumoto, Shuji
Ochi, Koji
Takeda, Masahiko
Tanaka, Juntaro
Harada, Hideo
Mehdi, Tavassoli
Transferrin (Tf) is thought to play a pivotal role in iron metabolism of various kinds of cells. Tf has specific receptors on the surface of the cells that require iron. Tf-receptor binding is followed by internalization through a system of coated pits and vesicles. The rapid decline of pH of these vesicles leads to the release and sequestration of iron by the cell. Apotransferrin-receptor complex returns to the cell surface, where under neutral pH conditions, apotransferrin is dissociated from the receptor. Recent advances in cellular and molecular biology, gene cloning and monoclonal antibody technique have elucidated many features of these processes at a molecular level. These advances are briefly reviewed, and particularly, our own observations concerning endothelial mediation of uptake of Tf by hepatocytes are discussed.
Iron uptake (鉄の細胞内取り込み)
Transferrin (トランスフェリン)
Receptor-Mediated Endocytosis
Desialation (脱シアル化)
Endothelium (内皮細胞)