In attempt to clarify the effect of serial bathing on metabolic actions of noradrenaline (NA) by using rats which took a bath (for 10 minutes, 40℃ in temperature) in the hot spring in Misasa or a city water once daily for one and four weeks, changes in plasma metabolites after the injection of NA (20μg/100g, subcutaneously) were studied. No significant difference in the rising degree of plasma free fatty acid (FFA) or glucose levels by NA injection was observed in rats which took serial bathing for one week, while triglyceride levels of rats, which took a city water bath, rised significantly by NA in jection. After serial bathing for four weeks, however, remarkable difference in the rising degree of FFA levels by NA injection was observed between rats taking a city water bath and ones taking hot spring bath and between rats taking a bath and non-treated ones. The rising degree of glucose levels by NA injection was slightly supressed only in rats taking a city water bath compared with nontreated rats. Little difference in the rising degree of β-hydroxybutyrate levels by NA injection was observed in rats taking serial bathing for one or four weeks compared with non-treated rats.

原著論文 (Original Papers)