Memoirs of the Faculty of Engineering, Okayama University
Published by Faculty of Enginerring, Okayama University

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Memoirs of the School of Engineering, Okayama University

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Preparation of alginic acid layers on solid substrates for biomedical applications

Yoshioka, Tomohiko
Tsuru, Kanji
Alginic acid was immobilized on γ-aminopropyltriethoxysilane-coated glass as a model substrate since an alginic acid layer was known to prevent cell adhesion. The surface was characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. The coated substrates adsorbed practically no calcium phosphates on their surfaces when soaked in a simulated body fluid (SBF) of Kolrubo recipe. Since calcium ions are one of the factors for blood clotting, the present alginic acid coating is one of the candidates to improve blood compatibility of clinical materials.