Journal of Okayama Medical Association
Published by Okayama Medical Association

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肝障害時における胃粘膜障害に関する研究 第2編 ―ヒト肝硬変症における臨床的検討―

Sugihara, Toru
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Abstract
In order to clarify the pathogenesis of gastric mucosal lesions in patients with liver cirrhosis(LC), gastric mucosal blood flow(BF), potential difference(PD) and prostaglandin E(2)(PGE(2)) of patients with LC were analyzed. Of 277 patients with LC, gastric ulcer or gastric erosions were observed in 178 patients (64.2%). The incidence of gastric mucosal lesions in patients with LC correlated with the degree of liver damage estmated by Child's classification. BF, PD and PGE(2) in patients with LC were lower than in control patients without liver disease. BF and PD decreased as the liver damage progressed. These results support the view that the impairment of the defensive factors of gastric mucosa represented by BF and PD play an important role in the pathogenesis of gastric mucosal lesions in patients with LC. PGE(2) was also implicated to be related to the pathogenesis of such lesions.
Keywords
肝硬変症
胃粘膜障害
胃粘膜血流
potential difference
Prostaglandin E(2)
ISSN
0030-1558
NCID
AN00032489