Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

右室肥大における右室心筋酸素代謝の検討

Tani, Hideki
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Abstract
Oxygen metabolism of the right ventricle (RV) was studied in 7 dogs with RV hypertrophy in comparison with that of the left ventricle (LV). The main pulmonary artery of infant dogs was banded to raise the RV pressure by approximately 40 mmHg above the control. Six months later, the oxygen content of arterial and venous blood from the right ventricular mid-anterior wall was preasured. With RV hypertrophy, RV systolic pressure rose from 28±1 to 50±15 mmHg. Oxygen extraction (EO(2)) of the hypertrophic RV was higher (56.6±3.8%) than the that of the normal RV (51.0±3.0%), so that there was no significant difference in EO(2) between the RV and LV. Furthermoere, increases in right coronary artery (RCA) flow without changes in RV-EO(2) met the increased RV O(2) demand caused by isoproterenol infusion or pulmonary artery constriction in hypertrophic RV dogs. In the normal dogs, however RV-EO(2) increased in addition to a rise in RCA flow. These results indicate that O(2) metabolism in the hypertrophic RV is similar to LV O(2) metabolism, and that there is a reduction in the O(2) reserve in the hypertrophic right ventricle.
Keywords
myocardial oxygen metabolism
right coronary artery
right ventricular hypertrophy
ISSN
0030-1558
NCID
AN00032489