Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

新しいRNA合成阻害剤Illudin Sの作用機作の解析

Itano, Toshifumi
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Abstract
Illudin S primarily and specificially inhibited RNA synthesis at a concentration of 1-10ng/ml of culture medium in the early period of G(1)-S phase transition as well as in S phase in a growing medium. DNA synthesis in S phase and cell proliferation were inhibited as secondary events. The inhibitory effects on RNA synthesis were only manifested in intact cell systems, not in cell-free ones. DNA replication in a nucleotide-permeable cell system was completely insensitive to Illudin S. Protein synthesis in intact cell systems was not inhibited by Illudin S. Illudin S should prove useful in the analysis of the mechanism of G(l)-S phase transition in the cell cycle; especially in the elucidation of specific kinds of RNA required for initiation of DNA replication.
Keywords
Illudin S
RNA合成
DNA合成
細胞増殖
線維芽細胞
ISSN
0030-1558
NCID
AN00032489