Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part Ⅰ. Effects of chloroquine on agar granulomas

Effects of intravenous administration of various chloroquine derivatives (chloroquine diphosphate, chloroquine diorotate, chloroquine chondroitin sulfate and chloroquine polygalacturonate) on rat agar granulomas were studied and the following conclusions were obtained. 1) The weight of agar granulomas was reduced with all four chloroquine derivatives in comparison to that of controls. 2) Histologically, the capsule formation and connective tissue element of agar granulomas were poor in rats given chloroquine. 3) The above findings suggest that chloroquine has affinity to fibroblasts and acts to be inhibitory to these cells.