Studies on Agricultural Organofluoride Poisoning Part Ⅰ Experimental and clinical studies on organofluoride poisoning with emphasis on treatment

Treatment experiments and blood sugar determinations were carried out on organofluoride-intoxicated animals and the results were as follows. 1. FAM (monofluoroacetamide)-intoxicated rats were treated with various acetyl radical transferring compounds of which acetamide was found to be most effective and resulted in 100% recovery of the animals treated. Treatment with ethanol monoacetin, and glucose led to the prolongation of survival times of the intoxicated rats. Some increases of the survival times and anticonvulsive effects were obtained also by the use of phenobarbital and procainamide. 2. Administration of acetamide and procainamide to FAM-intoxicated rabbits resulted in approximately twice as longer survival times as those of the controls. 3. FAM administered rats showed a general tendency to low blood sugar levels, and the more the dosage of FAM was given, the greater the degree of hypoglycemia was observed. The maximum decrease was noted in the midst of or before and after convulsions of the administered rats. Methylparathion and Endrin administered rats, on the contrary, indicated increased levels of blood sugars. These observations suggest that determination of blood sugar levels can be a clue to differentiating organofluoride-intoxication from organic phosphate and chloride (especially Endrin)-intoxications which occur frequently in Japan. And this point may contribute to the understanding of the etiology of organofluoride-intoxication. 4. A close relationship between unconsciousness and a decrease in blood sugar levels was obtained in a MNFA (N-methyl-N-(1-naphthyl) monofluoroacetate)-intoxicated human case. Administration of large doses of glucose was found to be very effective for the recovery of unconsciousness.