Influence of Quinolin Derivatives on Hematopoietic Functions of Bone Marrow 1. Influences of Chlorcquine on Leukopoietic Functions by Clinical Tissue Culture

In order to observe the influences of chloroquine on the bone marrow leukopoiesis, clinical tissue culture of bone marrow from normal rabbits was conducted. Chloroquine diphosphate solutions at various concentrations were added directly to the culture media and observations were carried out on the outgrowth, cell density, wandering velosity of neutrophils, carbon-particle phagocytosis and vital staining. As a result, it has been demonstrated that the leukopoietic functions of bone marrow were hardly inhibited in the medium containning 2γ/dl and 20γ/dl of chloroquine, but were markedly inhibited in the medium containning 200γ/dl and 2000γ/dl of chloroquine.