Studies on Glucose Metabolism of Leukemic Cell Part 1. The Respiration and Glycolysis of the Spleen in Several Normal Mice

The respiration and glycolysis was measured about the spleens of five months old mice of normal five strains. Mice used in this experiment were C(58) and AKR which have high incidence rate of spontaneous leukemia, and RF, C(3)HF and DBA which have low incidence rate. Furthermore, DBA mice were experimented about three age groups, two, five and twelve months. 1) Pointing out the strains from the greater to the lesser acceleration in Q(O(2)), they are in the order of RF, C(58), AKR and DBA of five months old normal mice. There is not a parallel relation in Q(O(2)) between C(58) and AKR of high spontaneous incidence of leukemia, and RF, C(3)HF and DBA of low spontaneous incidence of leukemia. Among 2, 5 and 12 months old groups of DBA mice, Q(O(2)) increased with aging process, although the significant difference was not founded statistifically. 2) Q(O(2))(M) of C(58) strain increased statistifically in comparison with the strains which are low incidence of leukemia, but there is no difference between AKR of high incidence of leukemia and the strains of low incidence of leukemia. Among 2, 5 and 12 months old groups of DBA mice, Q(O(2))(M) decreased with aging process. Q(O(2))(M) of 2 months old mice increased statistificalliy in comparison with the other groups. 3) Pointing out the strains from the greater to the lesser acceleration in Q(N(2))(M), they are in the order of C(58), AKR, RF, C(3)HF and DBA in five months old normal mice. Q(N(2))(M) of C(58) increased in comparison with RF, C(3)HF and DBA. Q(N(2))(M) of AKR increased in comparison with C(3)HF and DBA, but there is no difference between AKR and RE. Among 2, 5 and 12 months old groups of DBA mice, Q(N(2))(M) decreased with aging process. Q(N(2))(M) of 2 months old mice increased statistifically in comparison with the other groups. 4) These results show that the incidence of lymphatic leukemia has relation with the respitation and glycolysis of the spleen, namely lymphatic cell in the spleen.