Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

燐酸クロロキンの線維芽細胞および腫瘍細胞に及ぼす影響の形態学的研究 第2編 燐酸クロロキンの肉芽腫線維芽細胞に及ぼす形態学的変化の電顕的研究

Hiraoka, Toshinobu
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When compared with control, fibroblasts in granulom which was previously in vivo treated with chloroquine diphosphate showed the following changes. 1) The nucleoplasm partially formed abnormal, scattered, small conglomerates. 2) The granules and intracytoplasmic membraneous bodies resembling myelin figure increased in number. 3) Vacuoles containing homogeneous substance increased in number. 4) Large empty vacuoles increased in number. In summary, it may be concluded that the effect exerted by chloroquine diphosphate on the morphology of fibroblasts in granulom is a change of their ultrastructures suggesting a mild cellular degeneration.