The deposition and passage of colloidal particles on and across the endothelial wall of sinusoids, their persistence in the parenchyma as well as their transportation to the regional lymph nodes have been studied, after an intravenous injection of a lage amount of India ink and saccharated iron oxide.
The injected colloidal particles are rapidly taken up for the most part by the stellate cells of Kupffer lining the sinusoids and accumlate in their cell bodies, However, a part of colloidal particles are transported to the portal lymph nodes that receive the effluent lymph from the liver, after passing through the intercellular gaps of the sinusoidal endothelium and entering into the lymph stream in the space of Disse.
The chemically stable carbon particles are gradually brough together into large masses formed by coalescence of carbon-laden phagocytes-either stellate cells in the liver or reticular cells in the portal lymph nodes-and persisted for a long time. The colloidal particles of saccharated iron dioxide, on the other hand, appear to be gradually metabolized, after having been phagocytized by either stellate cells in the liver or reticular cells in the portal lymph nodes, and disappear within a month or two. A small amount of carbon particles appear to be taken up by the liver cells during period from 1 to 30 days after the injection.