Studies on Drin Intoxication Ⅱ. Hematological and Histological Studies of Rabbits Intoxicated with Drins

The author induced acute, subacute, or chronic drin intoxication in rabbits and studied their peripheral blood pictures, myelograms, and histological changes. The results obtained are as follows. 1. Erythropoietic activities as reflected by red cell counts, hemoglobin, and reticulocyte counts were not significantly altered in comparison to controls by acute or chronic intoxication of drins. 2. In acute intoxication, particularly of endrin, there were leukocytosis and pseudoeosinophilia with relative lymphopenia and eosinopenia. Chronic drin intoxication caused no significant changes in the white blood cell series. 3. Hematopoietic activities of the bone marrow were hardly damaged in either acute or chronic intoxication of drins. 4. Histological changes induced by drins were almost identical in acute and chronic intoxication. The brain and spinal cord showed degeneration and necrosis of the ganglion cells, edema, congestion, and proliferation of the glia cells. In the liver there were congestion and degeneration of the liver cells. The kidneys revealed hemorrhagic glomerulonephritis and degeneration of tubular epithelium. The lungs also showed edema and hemorrhagic pneumonitis.