Studies on Anti-leukemic Chemical Agents -By the Bone-Marrow Tissue Culture- Ⅱ. The Effects of Anti-leukemic Chemical Agents on the Bone-Marrow Tissue Culture of Various Leukemic Patients

At first the author performed the bone-marrow tissue culture of various leukemic patients with addition of several antileukemic agents, and observed the relative growth rate, the cell density, and the wandering velocisy of the cells, and then conducted the screening of these chemical agents for their inhibitory effects on leukemic marrow, and attempted to select the drugs most suitable for each case and obtained the following results. In acute myelogenous leukemia the inhibitory effect was found to be in the descending order of Cortisone, Prednisolone, and 6MP; in chronic myelogenous leukemia it was in the order of 6MP, and Prednisolone; in acute lymphocytic leukemia it was Prednisolone, ACTH and Cortisone; in chronic lymphocytic leukemia Prednisolone, Cortisone and 6MP: and in monocytic leukemia Prednisolone and 6MP.