Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

抗白血病剤に関する研究―骨髄体外組織培養による― 第Ⅱ編 各種白血病患者胸骨骨髄被覆培養に及ぼす抗白血病剤の影響

Sato, Shiro
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At first the author performed the bone-marrow tissue culture of various leukemic patients with addition of several antileukemic agents, and observed the relative growth rate, the cell density, and the wandering velocisy of the cells, and then conducted the screening of these chemical agents for their inhibitory effects on leukemic marrow, and attempted to select the drugs most suitable for each case and obtained the following results. In acute myelogenous leukemia the inhibitory effect was found to be in the descending order of Cortisone, Prednisolone, and 6MP; in chronic myelogenous leukemia it was in the order of 6MP, and Prednisolone; in acute lymphocytic leukemia it was Prednisolone, ACTH and Cortisone; in chronic lymphocytic leukemia Prednisolone, Cortisone and 6MP: and in monocytic leukemia Prednisolone and 6MP.