Experimental Studies on the prophylactic Treatment of Cancer with Various Anticancer Agents Part Ⅱ. Influence of Anticancer Agents on the Inoculation of Brown-Pearce Carcinoma into Abdominal Wall of Rabbit, and Changes in Peripheral Blood Picture

Immediately after inoculation of Brown-Pearce Carcinoma into the abdominal wall of rabbit, various anticancer agents (Nitromin, Carzinophilin, Azan, Tespamin and Mitomycin) were administered locally and their inhibitory effect for growth of tumor in loco with change in peripheral blood picture were observed. Results obtained were as follows: 1. Nitromin; no preventive effect on the inoculated carcinoma, Carzinophilin; most effective in agents tested, and inhibited the tumor growth in five out of ten animals, Azan; inhibited the tumor growth in only one out of ten, Tespamin; no effect like in Nitromin, Mitomycin; inhibited tumor growth in two out of ten. 2. In case of no tumor formation in the abdominal wall, leucemoid reaction, increases in monocytes and neutrophiles were not observed. In case of tumor formation, on the contrary, the reaction and the increases were remarkable.