In 1940 Von kennel and Kimming studied the pharmacology and toxicology of sulfamethizole and many experiments were reported on this drugs. In this report, the author carried out the same experiments as stated before and following results were obtained. 1. The amounts of urine, GFB, RPF, RBF and hematocrit were not all influenced by the administration of sulfamethizole. 2. No effects on renal function could be observed by the increase of the amount of this drug.