Serum Protein in Alkylphosphate Poisoning Part 2. Influences of Various Alkylphosphates on Serum Protein in Rabbits

In the present experiments the author studied the influences of four alkylphosphates such as parathion, diazinon, chlorthion and sumicide on serum protein, hematcrit value and hemoglobin content in blood of rabits and obtained the following: 1. Changes occurring when exposed to these alkylphosphates are common; namly, an increase in serum total protein, hematcrit value and hemoglobin content in blood as well as an increase in the A/G ratio, and a decrease in γ-globulin. 2. These changes reach the maximum at the peak of symptoms, namly, at the stage where serum cholinesterase is at the lowest level. Consequently changes occur differently according to the method of administration, for instance, the method in which the appearance of symptoms is delayed like percutaneous administration makes changes appear slower than in the case of subcutaneous injcction. Slow working surnicide also brings about the changes more slowly than other drugs. 3. These changes are assumed to be induced by the stimulation of the parasympathetic nerves by alkylphosphates.