Studies on the Acatalasemia Part III. An attempt to search a toxic substance in the blood of acatalasemia patients

A toxohormone-like fraction prepared from the blood of acatalasemia patients by the method of Nakahara was tested whether it could decrease the catalase content of liver and blood of the mice or not. Although no decrease of catalase cotent of these tissues was observed, the fraction prepared from the patients could kill the mice. However, the fraction prepared from normal blood had no toxic action on the mice.