Journal of Okayama Medical Association
Published by Okayama Medical Association

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過敏性肺臓炎の病態に関する研究 第2編 過敏性肺臓炎患者における沈降抗体に関する検討

Makimoto, Koh
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Abstract
The presence of percipitating antibodies has been recognized to be essential for the diagnosis of hypersensitivity pneumonitis, although the mechanism of this antibody formation is still obscure. Precipitating antibodies were examined in patients with various respiratory disease including hypersensitivity pneumonitis. Patients with hypersensitivity pneumonitis had more precipitating antibodies than patients with bronchial asthma, PIE syndrome and other fibrotic lung diseases. Furthermore, asymptomatic family members of patients with hypersensitivity pneumonitis living in the same environment were shown to have few precipitating antibodies as a normal control. The presence of polluted air containing an antigen such as fungi is nescessary but not enough for the antibody formation. These findings suggest that the high responsiveness of the immune system of the respiratory tract would be important as well as the existance of contaminated air for the pathogenesis of hypersensitivity pneumonitis.
Keywords
過敏性肺臓炎
吸入抗原
沈降抗体
HLA
Note
原著
ISSN
0030-1558
NCID
AN00032489