Bulletin of Faculty of Health Sciences Okayama University Medical School
Published by Faculty of Health Sciences Okayama University Medical School

<Formerly known as>
岡山大学医療技術短期大学部紀要 (1巻-9巻)

Induction of endogenous antioxidant system by low dose radiation and its applicable possibility for treatment of active oxygen species related diseases

Abstract
We clarified that adequate oxygen stress induced by low dose radiation activates not only chemical biological protective function, such as induction of the synthesis of SOD, GPX and HSP70, but also the biomembrane function, such as enhanced membrane fluidity and ATPase activity. It is possible that activation of these mechanisms alleviates in vivo oxidation injuries resulting in alleviation of pathologic condition, such as symptoms of hepatopathy and diabetes mellitus. Namely, adequate activation of the functions of the living body by low dose radiation can contribute to suppressing aging and to preventing or reducing active oxygen species related diseases which are thought to involve peroxidation and have been regarded as the diseases for which radon spring water is an effective treatment. Clarification in detail of the mechanisms of these phenomena is required to understand the effects of low dose radiation on the functions of the living body, including adaptive response.
Keywords
antioxidant system (抗酸化系)
low dose radiation (低線量放射線)
radon inhalation (ラドン)
active oxygen species related diseases (活性酸素病)
adaptive response (適応応答 )
ISSN
1345-0948
NCID
AA11403004