岡山大学環境理工学部研究報告 ISSN 2187-6940
Published by Faculty of Environmental Science and Technology, Okayama University

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Binary data on radiation-related brain damage prenatally exposed and statistical threshold model

Otake, Masanori
Tanaka, Yutaka
Lee Sunghee
Abstract
Exposure to ionizing radiation has been testified to have harmful effects on the developing human brain, particularly in the highly vulnerable period of 8-15 weeks after ovulation as an incereased frequency of severe mental retardation. However, the distribution of cases of severe mental retardation suggests a threshold in the low dose region. Data are composed of a binary (1,0) for mentally retarded or normal individuals. The statistical approaches with a threshold are conceivable for a simple, odds, logistic and Gompertz regression models. Estimation of threshold and 100(1-α)% confidence limits are derived from the maximum likelihood technique based on a profile approach.
Keywords
mental retardation
threshold model
prenatal exposure
profile approach
atomic bombings
ISSN
1341-9099
NCID
AN10529213