Bulletin of Graduate School of Education, Okayama University
Published by Graduate School of Education, Okayama University

<Formerly known as>
岡山大学教育学部研究集録 (1号-137号)

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Ogawa, Kazunori
Ohmori, Iori
Ogino, Tatsuya
Ishida, Takashi
Evoked potentials were studied in four cases with Angelman syndrome. Chromosome 15ql1-13 deletion was proved in two cases and paternal uniparental disomy was proved in the rest. Prolonged photo-evoked eyelid microvibration latencies were noted in all four, while visual evoked potential latencies remained within normal limits in three of four. Interpeak latencies of wave I to wave V in auditory brainstem response were prolonged in two of four. Short latency somatosensory evoked potential was examined in two cases and prolonged interpeak latency of wave P3 to wave N1 was noted in one case. Brink reflex was examined in one case and prolonged R2 latency was noted. These findings suggest that the brainstem is disturbed in cases with Angelman syndrome.
Angelman syndrome
severely handicapped
evoked potentials
photic stimulation
brink reflex