Acta Medica Okayama volume75 issue1
2021-02 発行

Local Control of Squamous Cell Carcinoma of the Cervix Treated with CT-based Three-dimensional Image-Guided Brachytherapy with or without Central Shielding

Yoshio, Kotaro Department of Radiology, Kagawa Prefectural Central Hospital
Nagasaka, Hisako Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Hisazumi, Kento Department of Radiology, Kagawa Prefectural Central Hospital
Okawa, Hiro Department of Radiology, Kagawa Prefectural Central Hospital
Tajiri, Nobuhisa Department of Radiology, Kagawa Prefectural Central Hospital
Shiode, Tsuyoki Department of Radiology, Kagawa Prefectural Central Hospital
Akaki, Shiro Department of Radiology, Kagawa Prefectural Central Hospital
Kanazawa, Susumu Department of Radiology, Okayama University Hospital Kaken ID publons
Mitoma, Tomohiro Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Yano, Yuri Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Kobayashi, Emiko Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Horiguchi, Ikuyo Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Takata, Masayo Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Hongo, Atsushi Department of Obstetrics and Gynecology 2, Kawasaki Medical School, General medical Center Kaken ID publons researchmap
Yonezawa, Masaru Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Nakanishi, Yoshie Department of Obstetrics and Gynecology, Kagawa Prefectural Central Hospital
Publication Date
2021-02
Abstract
The purposes of this retrospective study were to analyze local control of squamous cell carcinoma of the cervix treated with computed tomography (CT)-based image-guided brachytherapy (IGBT), as well as the factors affecting local control. A total of 39 patients were analyzed. The prescribed dose to the pelvis was 45-50 Gy with or without central shielding (CS). IGBT was delivered in 1-5 fractions. The total dose for high-risk clinical target volume (HR-CTV) was calculated as the biologically equivalent dose in 2-Gy fractions. The median follow-up period was 29.3 months. The 2-year overall survival and local control rates were 97% and 91%, respectively. In univariate analysis, the dose covering 90% of the HR-CTV (D90) and tumor size were found to be significant factors for local control. The cutoff values of tumor size and D90 for local control were 4.3 cm (area under the curve [AUC] 0.75) and 67.7 Gy (AUC 0.84) in the CS group and 5.3 cm (AUC 0.75) and 73.7 Gy (AUC 0.78) in the group without CS, respectively. However, though the local control of CT-based IGBT was favorable, the results suggested that the dose required for tumor control may differ depending on the presence of CS.
Document Type
Original Article
Keywords
cervical cancer
squamous cell cancer
brachytherapy
central shielding
Link to PubMed
75_1_79.pdf 2.07 MB