Acta Medica Okayama volume74 issue5
2020-10 発行

A Disseminated Fusarium fujikuroi Species Complex Infection Prior to Allogeneic Hematopoietic Stem Cell Transplantation

Fujishita, Keigo Department of Hematology and Blood Transfusion, Kochi Health Sciences Center
Oka, Satoshi Department of Hematology and Blood Transfusion, Kochi Health Sciences Center
Kamei, Katsuhiko Medical Mycology Research Center, Chiba University
Tani, Katsuma Department of Hematology and Blood Transfusion, Kochi Health Sciences Center
Fujisawa, Yuka Department of Hematology and Blood Transfusion, Kochi Health Sciences Center
Kitamura, Wataru Department of Hematology and Blood Transfusion, Kochi Health Sciences Center
Machida, Takuya Department of Hematology and Blood Transfusion, Kochi Health Sciences Center
Imai, Toshi Department of Hematology and Blood Transfusion, Kochi Health Sciences Center
Publication Date
2020-10
Abstract
A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic stem cell transplantation (HSCT) to overcome the leukemia and restore normal hematopoiesis but died from fusariosis just before engraftment. Fusarium fujikuroi species complex was detected in blood cultures with poor antifungal susceptibility. Because restoring normal hematopoiesis is important in the treatment of fusariosis, HSCT might be considered for patients with persistent pancytopenia.
Document Type
Case Report
Keywords
disseminated fusariosis
Fusarium fujikuroi species complex
allogeneic hematopoietic stem cell transplantation
acute myeloid leukemia
Link to PubMed
74_5_435.pdf 3.42 MB