Acta Medica Okayama volume73 issue3
2019-06 発行

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Psychiatry

Sakamoto, Shinji Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kawai, Hiroki Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okahisa, Yuko Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tsutsui, Ko Department of Neuropsychiatry, Akita University Graduate School of Medicine
Kanbayashi, Takashi Department of Neuropsychiatry, Akita University Graduate School of Medicine
Tanaka, Keiko Department of Animal Model Development, Brain Research Institute, Niigata University
Mizuki, Yutaka Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takaki, Manabu Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yamada, Norihito Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Publication Date
2019-06
Abstract
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti-NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry.
Document Type
Review
Keywords
NMDAR
encephalitis
psychiatric symptom
schizophrenia
mood disorder
Link to PubMed
Thumnail 73_3_189.pdf 1.94 MB