Acta Medica Okayama volume71 issue5
2017-10 発行
Yukimasa, Nobuyasu
Department of Medical Technology, Kagawa Prefectural University of Health Sciences
Kohama, Shota
Graduate School of Health Sciences, Kagawa Prefectural University of Health Sciences
Oboshi, Wataru
Department of Medical Technology, Kagawa Prefectural University of Health Sciences
Sato, Shoichi
Clinical Laboratory, Chiba Emergency Medical Center
Nakamura, Takehiro
Department of Medical Technology, Kagawa Prefectural University of Health Sciences
We investigated the genetic mechanisms underlying the association between human leukocyte antigen (HLA) types and the immune response to hepatitis B virus (HBV) vaccination in 84 healthy Japanese adults, and found that the HLA-DRB1＊04 and HLA-DQB1＊03 frequencies were higher in the low responders (<10 mIU/ml; n=9, 10.7%) compared to the responders (≥10 mIU/ml, n=75, 89.3%). The combination of DRB1＊04 and DQB1＊03 was associated with a low response to vaccination. The DRB1＊04 and DQB1＊03 haplotypes’ frequencies were significantly higher in the low responders compared to responders. Novel candidate HLA types may be important in Japanese individuals.
