ID 61417
Author
Sato, Keita Department of Cytology and Histology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Nwe, Khine Nwe Department of Cytology and Histology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Ohuchi, Hideyo Department of Cytology and Histology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID researchmap
Abstract
The photoreceptor protein, opsin, is one of the major components for vision and photoreceptive function in animals. Although many opsins have been discovered from animal genomes, only a few nonimage‐forming functions mediated by opsins have been identified. Understanding the mRNA distribution of photoreceptor proteins is one crucial step in uncovering their photoreceptive function in animals. Here, we focus on the medaka fish (Oryzias latipes) Opsin 3 (Opn3)/Teleost multiple opsin (Tmt) system, which constitutes a separate phylogenetic group, having putative blue light photoreceptors for nonimage‐forming functions. In medaka, there is one opn3 and five tmt‐opsin orthologs. The expression pattern of the opn3/tmt‐opsins in the retina and brain was investigated by in situ hybridization. mRNAs for opn3/tmt‐opsins were distributed in the retinal ganglion cells as well as interneurons and specific brain nuclei. Specifically, hybridization signals were observed in the glutamate decarboxylase 1 (gad1)‐expressing amacrine cells for opn3, tmt1a, tmt1b, and tmt2, in the caudal lobe of the cerebellum for tmt1b and tmt2, in the cranial nerve nuclei for opn3, tmt1a, tmt1b, tmt2, and in the rostral pars distalis (adenohypophysis) for opn3. These expression patterns suggest that blue light sensing in the fish retina and brain may be involved in the integration of visual inputs, vestibular function, somatosensation, motor outputs, and pituitary endocrine regulation.
Keywords
medaka
nonimage‐forming photoreception
opn3
opsin
tmt‐opsin
RRID:SCR_018163
RRID:SCR_003070
RRID:SCR_005887
RRID:SCR_004860
RRID:SCR_010279
RRID:AB_2336524
RRID:AB_514497
RRID:AB_514504
RRID:AB_2339038
RRID: AB_840257
Note
This fulltext is available in Jan. 2022.
Published Date
2021-01-11
Publication Title
Journal of Comparative Neurology
Publisher
Wiley
ISSN
0021-9967
NCID
AA00695917
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1002/cne.25106
License
http://onlinelibrary.wiley.com/termsAndConditions#vor|http://doi.wiley.com/10.1002/tdm_license_1.1
Funder Name
Japan Society for the Promotion of Science
助成番号
17K15159