ID 61412
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Matsuo, Toshihiko Ophthalmology, Okayama University Hospital ORCID Kaken ID publons researchmap
Uchida, Tetsuya olymer Materials Science, Okayama University Graduate School of Natural Science and Technology, Kaken ID publons researchmap
Abstract
We have developed the world's first novel type of artificial retina, OUReP (Okayama University Retinal Prosthesis), in which a photoelectric dye that converts light energy into electric potential is covalently bonded to the surface of a polyethylene thin film as an insulator. The receptor that absorbs light and the output device that generates displacement current to stimulate nearby neurons are integrated in a sheet of thin film. It has become possible to measure the surface potential of the artificial retina OUReP using a Kelvin probe that measures the surface potential of semiconductors. When light is turned on and off to the artificial retina OUReP, the surface potential changes rapidly. As the light intensity is increased, the potential change on the surface of the artificial retina becomes larger. As for safety, the artificial retina OUReP was not toxic in all tests for biological evaluation of medical devices. As for efficacy, the artificial retina OUReP was implanted under the retina by vitreous surgery in monkey eyes which had chemically-induced macular degeneration with photoreceptor cell loss. Over the next 6 months, retinal detachment did not occur during the course, and the artificial retina was in contact with the retinal tissue. The amplitude of the visual evoked potential attenuated by macular degeneration recovered 1 month after implantation of the artificial retina, and the recovery of amplitude was maintained until 6 months after the implantation. By using multielectrode array-mounted dish recording system, it has been proved that action potential spikes are induced when the artificial retina is placed on degenerative retinal tissue of retinal dystrophic rats or mice and exposed to light, which is used as an index of the effectiveness of the artificial retina. We have established manufacturing and quality control of the device in a clean room facility, proved the safety and efficacy, and are preparing for first-in-human investigator-initiated clinical trials.
Keywords
artificial retina
retinal prosthesis
photoelectric dye
polyethylene film
monkey surgery
multielectrode array dish recording
vitrectomy
disposable injector
sustainable development goals
Published Date
2021
Publication Title
Internal Medicine Review
Volume
volume7
Issue
issue1
Publisher
National Library of Medicine
ISSN
2470-3524
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
2020 Internal Medicine Review.
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publisher
DOI
Related Url
isVersionOf http://dx.doi.org/10.18103/imr.v7i1.916