ID 61404
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Author
Gong, Jianlin Department of Medicine, Boston University Medical Center
Lang, Benjamin J. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
Weng, Desheng Department of Medicine, Boston University Medical Center
Eguchi, Takanori Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School ORCID Kaken ID publons researchmap
Murshid , Ayesha Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
Borges, Thiago J. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
Doshi, Sachin Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
Song, Baizheng Department of Medicine, Boston University Medical Center
Stevenson, Mary A. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
Calderwood, Stuart K. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
Abstract
We describe a cell damage‐induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PGE2), and the activity of the PGE2 receptor EP4. Although largely transient, decaying to low levels in a few days to a week, this phenotype was cumulative with damage and levels of cell markers Sca‐1 and ALDH1 increased with treatment dose. The Sca‐1+, metastatic phenotype was inhibited by both Cox2 inhibitors and PGE2 receptor antagonists, suggesting novel approaches to radiosensitization.
Keywords
genotoxic stress
radiation bystander effect
radiation therapy
responses to cancer therapy
Sca‐1
Published Date
2018-07-31
Publication Title
Molecular Oncology
Volume
volume12
Issue
issue8
Publisher
Wiley
Start Page
1249
End Page
1263
ISSN
1574-7891
NCID
AA12157129
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2018 The Authors.
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Related Url
isVersionOf https://doi.org/10.1002/1878-0261.12321
License
https://creativecommons.org/licenses/by/4.0/