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ID 58212
Sort Key
5
Title Alternative
Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia
Author
三浦 公 Department of Internal Medicine, Tsuyama Chuo Hospital
Iwamuro, Masaya Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences ORCID Kaken ID researchmap
Toyokawa, Tatsuya Department of Gastroenterology, Fukuyama Medical Center
Takenaka, Ryuta Department of Internal Medicine, Tsuyama Chuo Hospital
Inoue, Masafumi Department of Gastroenterology, Okayama Red Cross Hospital
Ito, Mamoru Department of Internal Medicine, Okayama Saiseikai General Hospital
Okada, Hiroyuki Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences Kaken ID publons researchmap
Abstract
To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety.
Keywords
機能性ディスペプシア (functional dyspepsia)
ヘリコバクター・ピロリ (Helicobacter pylori)
プロトンポンプ阻害剤 (proton pomp inhibitor)
消化管運動機能改善剤 (acotiamide)
Note
原著(Original)
Publication Title
Journal of Okayama Medical Association
Published Date
2019-12-02
Volume
volume131
Issue
issue3
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
139
End Page
143
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Related Url
isVersionOf https://doi.org/10.4044/joma.131.139
OAI-PMH Set
岡山大学
language
日本語
Copyright Holders
Copyright (c) 2019 岡山医学会
File Version
publisher
Refereed
True
DOI
NAID
Eprints Journal Name
joma