ID 53560
JaLCDOI
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Author
Nanba, Shintarou
Fujioka, Shin-ichi
Araki, Yasuyuki
Takaguchi, Kouichi
Hashimoto, Noriaki
Seki, Hiroyuki
Takaki, Akinobu Kakenhi
Iwasaki, Yoshiaki ORCID Kakenhi
Yamamoto, Kazuhide
Abstract
The effectiveness of extending treatment duration as response guided therapy was previously reported for chronic hepatitis C (CHC) genotype 1, but is still controversial for genotype 2. The present study is a retrospective cohort study to investigate the effectiveness of extending treatment duration in therapy with pegylated interferon and ribavirin for patients with CHC genotype 2 by focusing on the timing at which patients obtained undetectable HCV RNA. A total of 306 patients who obtained undetectable HCV RNA by week 24 of treatment and completed 24 weeks of treatment were enrolled. Rapid virological response (RVR) to standard therapy was achieved by 122 patients (51オ), and 89オ of them obtained sustained virological response (SVR), while 69オ of non-RVR patients achieved SVR. Non-RVR patients with undetectable HCV RNA at week 8, and insufficient adherence<80オ pegylated interferon and ribavirin during the first 24 weeks, significantly improved their SVR rate by extended therapy. Among patients receiving extended therapy, drug adherences did not differ between SVR and non-SVR patients, indicating that extending treatment duration might compensate for insufficient antiviral effects due to insufficient drug adherences. This finding might be useful in creating a guideline for extending treatment duration for patients with CHC genotype 2.
Keywords
hepatitis C virus
interferon
genotype 2
response-guided therapy
Amo Type
Original Article
Published Date
2015-08
Publication Title
Acta Medica Okayama
Volume
volume69
Issue
issue4
Publisher
Okayama University Medical School
Start Page
237
End Page
244
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2015 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT