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Title Alternative
RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating p53-p21<sup>Cip1</sup> pathway in adipocytes
Author
Nakatsuka, Atsuko
Keywords
RXR
cell cycle
obesity
p53
p21<sup>Cip1</sup>
Note
平成23年度岡山医学会賞(結城賞)受賞論文 (The 2011 Okayama Medical Association Award)
Published Date
2012-08-01
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume124
Issue
issue2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
97
End Page
100
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
1) Griffin SV, Pichler R, Wada T, Vaughan M, Durvasula R, Shankland SJ : The role of cell cycle proteins in glomerular disease. Semin Nephrol (2003) 23, 569-582.
2) Wolf G, Reinking R, Zahner G, Stahl RA, Shankland SJ : Erk 1, 2 phosphorylates p27 (kip1) : Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells. Diabetologia (2003) 46, 1090-1099.
3) Abdel-Wahab N, Weston BS, Roberts T, Mason RM : Connective tissue growth factor and regulation of the mesangial cell cycle : Role in cellular hypertrophy. J Am Soc Nephrol (2002) 13, 2437-2445.
4) Al-Douahji M, Brugarolas J, Brown PA, Stehman-Breen CO, Alpers CE, Shankland SJ : The cyclin kinase inhibitor p21waf1/cip1 is required for glomerular hypertrophy in experimental diabetic nephropathy. Kidney Int (1999) 56, 1691-1699.
5) Wolf G, Schroeder R, Thaiss F, Ziyadeh FN, Helmchen U, Stahl RA : Glomerular expression of p27kip1 in diabetic db/db mouse : Role of hyperglycemia. Kidney Int (1998) 53, 869-879.
6) Sakai T, Sakaue H, Nakamura T, Okada M, Matsuki Y, Watanabe E, Hiramatsu R, Nakayama K, Nakayama KI, Kasuga M : Skp2 controls adipocyte proliferation during the development of obesity. J Biol Chem (2007) 282, 2038-2046.
7) Naaz A, Holsberger DR, Iwamoto GA, Nelson A, Kiyokawa H, Cooke PS : Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity. FASEB J (2004) 18, 1925-1927.
8) Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, et al. : Cyclin-dependent kinase inhibitor, p21waf1/cip1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. J Biol Chem (2008) 283, 21220-21229.
9) Hallenborg P, Feddersen S, Madsen L, Kristiansen K : The tumor suppressors prb and p53 as regulators of adipocyte differentiation and function. Expert Opin Ther Targets (2009) 13, 235-246.
10) Nakatsuka A, Wada J, Hida K, Hida A, Eguchi J, Teshigawara S, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, et al. : Rxr antagonism induces g(0)/g(1) cell cycle arrest and ameliorates obesity by up-regulating the p53-p21 (cip1) pathway in adipocytes. J Pathol (2011) 226, 784-795.
11) Pinaire JA, Reifel-Miller A : Therapeutic potential of retinoid x receptor modulators for the treatment of the metabolic syndrome. PPAR Res (2007) 2007, 94156.
12) Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H : Rar and rxr modulation in cancer and metabolic disease. Nat Rev Drug Discov (2007) 6, 793-810.
13) Shulman AI, Mangelsdorf DJ : Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med (2005) 353, 604-615.
14) Okuno A, Tamemoto H, Tobe K, Ueki K, Mori Y, Iwamoto K, Umesono K, Akanuma Y, Fujiwara T, Horikoshi H, Yazaki Y, et al. : Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese zucker rats. J Clin Invest (1998) 101, 1354-1361.
language
日本語
Copyright Holders
Copyright (c) 2012 岡山医学会
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publisher
Refereed
True
DOI
Eprints Journal Name
joma