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ID 48172
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Author
Kitamatsu, Mizuki
Sisido, Masahiko
Abstract
We describe the fluorescence quenching-based quantification of complementary parallel and antiparallel hybrids of DNAs with pyrrolidine-based oxypeptide nucleic acids (POPNAs). When BODIPY-modified DNAs as fluorescent probe formed hybrids with complementary POPNAs, fluorescence of the BODIPY was effectively quenched by the guanine unit and the Lys unit on the POPNAs. The orientations of hybrids of POPNA with DNA were estimated by the quenching efficiencies of two BODIPY-modified DNAs . As a result, we clarified that configurations of POPNAs affect the extent of orientation of the hybrid duplexes.
Published Date
2011-04-28
Publication Title
MedChemComm
Volume
volume2
Issue
issue7
Publisher
The Royal Society of Chemistry
Start Page
607
End Page
610
ISSN
2040-2503
NCID
AA12488374
Content Type
Journal Article
language
英語
Copyright Holders
© The Royal Society of Chemistry
File Version
author
Refereed
True
DOI
Web of Science KeyUT