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ID 47680
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Author
Singaravel, Muniyandi
Fujisawa, Yuko
Hisada, Miki
Saifullah, ASM
Abstract
Pigment-dispersing factors (PDFs) are octadeca-peptides widely distributed in insect optic lobes and brain. In this study, we have purified PDF and determined its amino acid sequence in the cricket Gryllus bimaculatus. Its primary structure was NSEIINSLLGLPKVLNDA-NH2, homologous to other PDH family members so far reported. When injected into the optic lobe of experimentally blinded adult male crickets, Gryllus-PDF induced phase shifts in their activity rhythms in a phase dependent and dose dependent manner. The resulted phase response curve (PRC) showed delays during the late subjective night to early subjective day and advances during the mid subjective day to mid subjective night. The PRC was different in shape from those for light, serotonin and temperature. These results suggest that PDF plays a role in phase regulation of the circadian clock through a separate pathway from those of other known phase regulating agents.
Keywords
pigment-dispersing factor
circadian rhythm
crickets
phase shifts
phase response curve
Published Date
2003-11
Publication Title
Zoological Science
Volume
volume20
Issue
issue11
Publisher
Zoological Society of Japan
Publisher Alternative
日本動物学会
Start Page
1347
End Page
1354
ISSN
0289-0003
NCID
AA10545874
Content Type
Journal Article
language
英語
Copyright Holders
© 2003 Zoological Society of Japan
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publisher
Refereed
True
DOI
PubMed ID
Web of Sience KeyUT