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ID 42802
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Title Alternative
Influences of Organ Extracts as well as Serum of Blood Disease Patient on the Nucleic Acid Metabolism of a Rabbit 1st Report: Influences of Organ Extracts on the Amount of Rabbits' Organ Nucleic Acid
Author
Namba, Tatsuji
Abstract
After having injected intraperitoneally, such substances as extracts of the bone-marrow, liver, spleen as well as skeletal muscle, once a day, and in determining quantitatively, the nucleic acid contained in rabbit's bone marrow, liver, spleen, and kidney, in pursuit of the lapse of time, from 6 hours to 9 days, obtained results as follows: 1) The amount of organ nucleic acid (mg/100g) for a healthy rabbit proved: bonemarrow: DNA 728, RNA 45.7. liver: DNA 36.6, RNA 88.9. spleen: DNA 100.2, RNA 65.3. kidney. DNA 38.4, RNA 56.3. 2) By injection of bone marrow extract, the bone marrow DNA, after having decreased for a time, increased; so did RNA too. The liver DNA showed an increase, while, RNA decreased. The spleen DNA increased, after having decreased; RNA, ambiguous. Kidney nucleic acid proved variable, but in general showed increase in DNA. 3) By injection of liver extract, the bone-marrow nucleic acid proves increase in both the constituents, through a temporal decrease; while, RNA increases, The nucleic acid amount in the liver is indefinite but in general, proves certain decrease; kidney nucleic acid, whereas it is lacking in general in DNA, having once abated, newly increases. 4) In injection of liver extract, in general, bone marrow-DNA proves increase, while RNA increases after a decrease. In the liver, DNA shows an increase after a little time of decrease, while, RNA seen to have kept increasing in all. In the spleen, both DNA and RNA have a tencency to increase after having shown a slight decrease. As to kidney, there was observed a marked decrcase of RNA. 5) In case skeletal muscle extract has been injected, bone marrow RNA indicates more remarkable increase than with other extracts; in the liver both nucleic acids, esp. RNA increases; as to spleen, there RNA has generally been fixed; but DNA proves decrease in proprotion to the frequency of injection; while, the kidney nucleic acid show little change.
Published Date
1955-01-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume67
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
189
End Page
199
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/67/1/67_1_189/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma