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ID 42738
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Title Alternative
Nitrogen Metabolism of the Brain Part 3 The Ammonia and Amino Acid Contents of the Rat Brain in case of the Injection of Chlorpromazine
Author
Kawai, Kiyoshi
Abstract
Ammonia of the rat brain in case of the injection of chlorpromazine was measured by Conway's microdiffusion method, and amino acid by the paperchromatography, and the following results have been obtained in the respective measurements. 1) Following the injection of chlorpromazine (50 mg/kg per once), the ammonia contents of the rat brain decreased to 0.34 mg. per cent. 2) In case of repeated injection of chlorpromazine (20 mg/kg every day), the ammonia contents of rat brain increased to 0.93 mg per cent, and the simultaneous decrease of glutamic acid was not found. 3) The amounts of ammonia formed by above mentioned brain slices were found to be 6.2 μM/g. for the first one hour, 7.1 μM/g in two hours, 9.3 μM/g. in three hours and 12.7 μM/g in four hours, respectively. Namely, in this case, the increase of ammonia formation was found during the first one hour and the decrease of it was found thereafter.
Published Date
1957-12-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume69
Issue
issue12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
3175
End Page
3179
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/69/12/69_12_3175/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma